Morphogenesis

Morphogenesis is the process by which an organism, tissue or organ develops its shape. Morphogenesis is driven by various cellular and developmental processes including cell proliferation, differentiation, apoptosis, cell migration and cell adhesion.

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  • News and Views |

    Embryonic stem cells derived from the inner cell mass can differentiate to all embryonic lineages of any adult cell type and to a limited extent to extra-embryonic tissues. A study now allows the generation of pig and human stem cells with enhanced differentiation potential towards all embryonic and extra-embryonic fates, one step closer to the totipotent state of the fertilized egg.

    • Fred Etoc
    •  & Ali Brivanlou
    Nature Cell Biology 21, 671-673
  • Research Highlights |

    A study in Nature describes a CRISPR–Cas9-based ‘molecular recorder’ that can report on cellular state and cell lineage, in mice, from fertilization through to adulthood.

    • Katharine H. Wrighton
  • Research Highlights |

    A new study in Science reports the existence of a subpopulation of somatic cells from which ‘elite’ clones emerge that outperform other clones to drive reprogramming.

    • Linda Koch
  • News and Views |

    Osteoclasts are known for their role in bone resorption. A study now shows that a vascular–associated osteoclast subtype at the growth plate also regulates blood vessel growth in bone and is supported by type H endothelial cells. These type H capillaries, in turn, release proteinases that promote cartilage degradation.

    • Jameel Iqbal
    •  & Mone Zaidi
    Nature Cell Biology 21, 417-419
  • News and Views |

    Epithelial–mesenchymal transition (EMT) is crucial for development, and for dissemination and invasion of cancer cells. A study now identifies the apical–basolateral polarity status of epithelia as a checkpoint for EMT induction and tumour metastasis through aPKC–Par3-regulated degradation of the EMT transcription factor SNAI1.

    • Oana-Diana Persa
    •  & Carien M. Niessen
    Nature Cell Biology 21, 299-300