Gastrulation

Definition

Gastrulation is the process during which the early sphere-like embryo of most animals is dramatically re-organised by the inward migration of cells on the outside of the embryo. During gastrulation, the three primary germ cell layers that will give rise to specific tissues and organs are formed.

Latest Research and Reviews

  • Research | | open

    Large-scale tissue reorganization requires the generation of directional tension, which requires orientation of the cytoskeleton. Here Chanet et al. alter tissue shape and tension in the Drosophila embryo to show that geometric and mechanical constraints act as cues to orient the cytoskeleton and tension.

    • Soline Chanet
    • , Callie J. Miller
    • , Eeshit Dhaval Vaishnav
    • , Bard Ermentrout
    • , Lance A. Davidson
    •  & Adam C. Martin
  • Research |

    Zebrafish neuroectoderm morphogenesis is influenced by the mesoderm germ layer. Smutny et al. now show that friction forces between cells moving in opposite directions, mediated by E-cadherin adhesion, determine the position of the neural anlage.

    • Michael Smutny
    • , Zsuzsa Ákos
    • , Silvia Grigolon
    • , Shayan Shamipour
    • , Verena Ruprecht
    • , Daniel Čapek
    • , Martin Behrndt
    • , Ekaterina Papusheva
    • , Masazumi Tada
    • , Björn Hof
    • , Tamás Vicsek
    • , Guillaume Salbreux
    •  & Carl-Philipp Heisenberg
    Nature Cell Biology 19, 306–317
  • Research | | open

    The progenitor populations that contribute to the key cardiac lineages in a chamber-specific manner are unknown. Here, the authors identify Foxa2+ progenitor population, which is specified at gastrulation, as contributing primarily to cardiovascular cells of both ventricles and the epicardium in mice.

    • Evan Bardot
    • , Damelys Calderon
    • , Francis Santoriello
    • , Songyan Han
    • , Kakit Cheung
    • , Bharati Jadhav
    • , Ingo Burtscher
    • , Stanley Artap
    • , Rajan Jain
    • , Jonathan Epstein
    • , Heiko Lickert
    • , Valerie Gouon-Evans
    • , Andrew J. Sharp
    •  & Nicole C. Dubois
  • Research | | open

    Mechanical signals regulate tissue differentiation but how this triggers downstream biochemical signals is unclear. Here, the authors place micro-magnets in the Drosophila embryonic epithelia and show this triggers apical pulsations, in turn stabilizing Myosin-II, resulting in mesoderm invagination.

    • Démosthène Mitrossilis
    • , Jens-Christian Röper
    • , Damien Le Roy
    • , Benjamin Driquez
    • , Aude Michel
    • , Christine Ménager
    • , Gorky Shaw
    • , Simon Le Denmat
    • , Laurent Ranno
    • , Frédéric Dumas-Bouchiat
    • , Nora M. Dempsey
    •  & Emmanuel Farge
  • Research |

    Inactivation of three Tet genes in mice leads to gastrulation phenotypes similar to those in embryos with increased Nodal signalling, revealing a functional redundancy of Tet genes and showing balanced and dynamic DNA methylation and demethylation is crucial to regulate key signalling pathways in early body plan formation.

    • Hai-Qiang Dai
    • , Bang-An Wang
    • , Lu Yang
    • , Jia-Jia Chen
    • , Guo-Chun Zhu
    • , Mei-Ling Sun
    • , Hao Ge
    • , Rui Wang
    • , Deborah L. Chapman
    • , Fuchou Tang
    • , Xin Sun
    •  & Guo-Liang Xu
    Nature 538, 528–532