Medicinal chemistry articles within Polymer Journal

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• Original Article | 26 February 2020

  Efficient synthesis, characterization, and application of biobased scab-bionic hemostatic polymers

  A series of polymeric hemostatic materials are prepared in one-step, by using biobased lactic acid monomers and mature hemostatic drugs (4-aminomethylbenzoic acid or tranexamic acid) through direct melt polycondensation. These materials are powdery with rough and irregular surfaces, and the powder particle size is ~8–30 μm, which is beneficial to the application, immediate hemostasis and scab-bionic membrane forming. Moreover, after the degradation of these materials at 37 °C, more monomers will be released, resulting in a higher efficiency and long-term hemostatic function.

  • Jian-Yun Lin
  • , Shi-He Luo
  •  & Zhao-Yang Wang

• Note | 29 November 2019

  Direct preparation of gels from herbal medicinal plants by using a low toxicity liquid zwitterion

  Gels containing the medicinal ingredients of licorice were formed by dissolving herbal medicinal plants into a biocompatible zwitterionic cellulose solvent and successive precipitation. The licorice gels gradually released glycyrrhizic acid, the main medicinal ingredient in licorice, within 3 h. Although the licorice gels were mechanically weak, the gel strength was improved just by the addition of cellulose during the preparation of the gels.

  • Chiaki Kodo
  • , Kosuke Kuroda
  •  & Kenji Takahashi

• Original Article | 01 April 2015

  Visualizing spontaneous physisorption of non-charged π-conjugated polymers onto neutral surfaces of spherical silica in nonpolar solvents

  Three non-charged π-conjugative polymeric fluorophores, that is, poly(di-n-octylfluorene; PF8), poly[(9,9-dioctylfluorenyl-2,7-diyl)-alt-bithiophene] and poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene], spontaneously physisorbed onto the neutral surface of 0.5-μm-sized spherical silica and four other ceramics in common nonpolar organic solvents within several hrs at room temperature. This process was observed via photoluminescence and excitation spectra. Attractive van der Waals interactions between the polymers and ceramics are responsible for the solution-phase physisorption. Surprisingly, the highest fraction (51–56%) of β-phase PF8 was found to deposit at the surface without thermal treatment.

  • Ayako Nakao
  •  & Michiya Fujiki