Abstract
Under optimized reaction conditions, by directly using the hemostatic drugs 4-aminomethylbenzoic acid (ABA) and tranexamic acid (TA) as separate comonomers of lactic acid (LA), a series of copolymers, P(LA-co-ABA) and P(LA-co-TA), respectively, with different molar feed ratios were designed and synthesized via melt polycondensation and used as biobased polymeric sustained-release hemostatic materials. Their structure, properties and morphology were systematically investigated by Fourier transform infrared spectrometer (FTIR), proton nuclear magnetic resonance (1H NMR), gel permeation chromatography (GPC), X-ray diffraction (XRD), differential scanning calorimetery (DSC), thermogravimetric (TG), scanning electron microscopy (SEM), water contact angle and degradation tests. The degradation rate within 7 weeks can reach 77%. When the molar feed ratios of ABA and TA are 20% and 10%, respectively, the corresponding copolymers have relatively lower crystallinity and smaller water contact angle and exhibit the best coagulation performance. In addition, these powdery copolymers have good application convenience, can form a degradable protective membrane similar to a blood scab on the wound surface and continuously exert hemostatic effects to promote wound healing, as anticipated.
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Acknowledgements
This research was supported by the Science and Technology Program of Guangzhou (No. 201607010301), the Open Fund of the Key Laboratory of Functional Molecular Engineering of Guangdong Province in SCUT (No. 2017kf01), the National Natural Science Foundation of China (20772035), and the Guangdong Provincial Science and Technology Project (No. 2017A010103016).
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Lin, JY., Luo, SH., Chen, SH. et al. Efficient synthesis, characterization, and application of biobased scab-bionic hemostatic polymers. Polym J 52, 615–627 (2020). https://doi.org/10.1038/s41428-020-0315-z
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DOI: https://doi.org/10.1038/s41428-020-0315-z
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