Medicinal chemistry articles within Nature Reviews Gastroenterology & Hepatology

Featured

• Review Article | 23 April 2018

  Systems biology in hepatology: approaches and applications

  Biological network models can provide a scaffold for studying the biological pathways operating in connection with disease development. Here, the authors review how biological network models can integrate multiomics data to advance our understanding of complex liver diseases, which might lead to improved treatment strategies.

  • Adil Mardinoglu
  • , Jan Boren
  •  & Jens Nielsen

• Comment | 29 November 2017

  The devotion to surrogate outcomes in drug development for liver disease

  Surrogate end points are often used in clinical trials where the time to clinical outcomes is long. In patients with liver disease, these surrogate outcomes are rarely validated. Without validation, treatment effects reported in trials might not directly translate to patient benefit after licensing.

  • Ian A. Rowe

• Research Highlight | 09 March 2016

  Snail venom for gut pain?

  • Iain Dickson

• In Brief | 17 February 2016

  A new chimeric model of hepatitis E infection

  • Iain Dickson

• In Brief | 06 December 2011

  Adalimumab promotes clinical remission in patients with ulcerative colitis