Drug discovery and development articles within Nature Reviews Gastroenterology & Hepatology

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  • Review Article |

    Biological network models can provide a scaffold for studying the biological pathways operating in connection with disease development. Here, the authors review how biological network models can integrate multiomics data to advance our understanding of complex liver diseases, which might lead to improved treatment strategies.

    • Adil Mardinoglu
    • , Jan Boren
    •  & Jens Nielsen

  • Comment |

    Surrogate end points are often used in clinical trials where the time to clinical outcomes is long. In patients with liver disease, these surrogate outcomes are rarely validated. Without validation, treatment effects reported in trials might not directly translate to patient benefit after licensing.

    • Ian A. Rowe

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