Drug delivery articles within Nature Reviews Gastroenterology & Hepatology

Featured

  • Year in Review |

    High stromal cellularity in pancreatic cancer is an important factor for ineffective treatment and molecular studies. In 2017, major advancements were made in transcriptional characterization, treatment delivery and clinical regimes, raising hope for a breakthrough against this deadly disease.

    • Alexander Semaan
    •  & Anirban Maitra

  • News & Views |

    Acute pancreatitis is the most common and feared complication following endoscopic retrograde cholangiopancreatography (ERCP). Pharmacological prevention of post-ERCP pancreatitis has been disappointing, especially in high-risk patients. However, a prospective multicentre trial has demonstrated the efficacy of rectal administration of indomethacin for preventing post-ERCP pancreatitis in high-risk cases.

    • Pier Alberto Testoni

  • News & Views |

    One of the major challenges in IBD therapy is targeting delivery of the drug to the specific site of inflammation. A recent approach to combat this problem is the use of nanoparticulate drug delivery systems that selectively accumulate a given drug at the site of affected tissue. As the drug load is delivered locally, drug dose and adverse effects are reduced.

    • Alf Lamprecht

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