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| Open AccessPKN1 kinase-negative knock-in mice develop splenomegaly and leukopenia at advanced age without obvious autoimmune-like phenotypes
- Salman Mahmud Siddique
- , Koji Kubouchi
- & Hideyuki Mukai
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| Open AccessTBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877
- Ricardo J. Antonia
- , Johnny Castillo
- & Robert S. Hagan
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| Open AccessVRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes
- Elena Martín-Doncel
- , Ana M. Rojas
- & Pedro A. Lazo
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| Open AccessIdentification of alkaline pH optimum of human glucokinase because of ATP-mediated bias correction in outcomes of enzyme assays
- Daniela Šimčíková
- & Petr Heneberg
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| Open AccessPhosphorylation of p23-1 cochaperone by protein kinase CK2 affects root development in Arabidopsis
- Stefano D’Alessandro
- , Serena Golin
- & Maria Ruzzene
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| Open AccessCharacterization of metal binding of bifunctional kinase/phosphatase AceK and implication in activity modulation
- Xiaoying Zhang
- , Qingya Shen
- & Zongchao Jia
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| Open AccessPaired Box-1 (PAX1) Activates Multiple Phosphatases and Inhibits Kinase Cascades in Cervical Cancer
- Po-Hsuan Su
- , Hung-Cheng Lai
- & Cheng-Chang Chang
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| Open AccessMutational mimics of allosteric effectors: a genome editing design to validate allosteric drug targets
- Qingling Tang
- , Maria T. Villar
- & Aron W. Fenton
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| Open AccessMycobacterial phosphatase PstP regulates global serine threonine phosphorylation and cell division
- Iswahyudi
- , Galina V. Mukamolova
- & Helen M. O’Hare
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| Open AccessA comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response
- Julia Roewenstrunk
- , Chiara Di Vona
- & Susana de la Luna
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| Open AccessNew type of interaction between the SARAH domain of the tumour suppressor RASSF1A and its mitotic kinase Aurora A
- T. Szimler
- , É. Gráczer
- & M. Vas
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| Open AccessGlobal response of diacylglycerol kinase towards substrate binding observed by 2D and 3D MAS NMR
- Kristin Möbius
- , Sina Kazemi
- & Clemens Glaubitz
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| Open AccessInvestigation of the phosphorylation of Bacillus subtilis LTA synthases by the serine/threonine kinase PrkC
- Frédérique Pompeo
- , Jeanine Rismondo
- & Anne Galinier
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| Open AccessStimulus strength determines the BTK-dependence of the SHIP1-deficient phenotype in IgE/antigen-triggered mast cells
- Carolin N. Zorn
- , Anne Simonowski
- & Michael Huber
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| Open AccessStructural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors
- André da Silva Santiago
- , Rafael M. Couñago
- & Jonathan M. Elkins
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| Open AccessNeuronal MAP kinase p38α inhibits c-Jun N-terminal kinase to modulate anxiety-related behaviour
- Kristie Stefanoska
- , Josefine Bertz
- & Arne Ittner
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| Open AccessAcylated-acyl carrier protein stabilizes the Pseudomonas aeruginosa WaaP lipopolysaccharide heptose kinase
- Naomi N. K. Kreamer
- , Rajiv Chopra
- & Tsuyoshi Uehara
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| Open AccessAdenosine Kinase couples sensing of cellular potassium depletion to purine metabolism
- Renata Rocha de Oliveira
- , Raphael Morales-Neto
- & Kleber Gomes Franchini
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| Open AccessBiochemical analyses reveal amino acid residues critical for cell cycle-dependent phosphorylation of human Cdc14A phosphatase by cyclin-dependent kinase 1
- Sara Ovejero
- , Patricia Ayala
- & María P. Sacristán
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| Open AccessIntrinsically active MEK variants are differentially regulated by proteinases and phosphatases
- Merav Ordan
- , Chiara Pallara
- & Rony Seger
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| Open AccessSympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis
- Esther Paulo
- , Dongmei Wu
- & Biao Wang
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| Open AccessIntegrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources
- Liang-Chin Huang
- , Karen E. Ross
- & Natarajan Kannan
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| Open AccessSrc signaling in a low-complexity unicellular kinome
- Hiroshi Suga
- & W. Todd Miller
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| Open AccessMultiBacMam Bimolecular Fluorescence Complementation (BiFC) tool-kit identifies new small-molecule inhibitors of the CDK5-p25 protein-protein interaction (PPI)
- Itxaso Bellón-Echeverría
- , Jean-Philippe Carralot
- & Imre Berger
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| Open AccessHigh yield bacterial expression, purification and characterisation of bioactive Human Tousled-like Kinase 1B involved in cancer
- Siddhant Bhoir
- , Althaf Shaik
- & Sivapriya Kirubakaran
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| Open AccessProtein interactomes of protein phosphatase 2A B55 regulatory subunits reveal B55-mediated regulation of replication protein A under replication stress
- Feifei Wang
- , Songli Zhu
- & Aimin Peng
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| Open AccessGSK3β modulates NF-κB activation and RelB degradation through site-specific phosphorylation of BCL10
- Ali Abd-Ellah
- , Cornelia Voogdt
- & Ralf B. Marienfeld
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| Open AccessArabidopsis serine/threonine/tyrosine protein kinase phosphorylates oil body proteins that regulate oil content in the seeds
- Iyappan Ramachandiran
- , Anitha Vijayakumar
- & Ram Rajasekharan
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| Open AccessStress-induced TRBP phosphorylation enhances its interaction with PKR to regulate cellular survival
- Evelyn Chukwurah
- & Rekha C. Patel
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| Open AccessEPHB6 and testosterone in concert regulate epinephrine release by adrenal gland chromaffin cells
- Yujia Wang
- , Wei Shi
- & Jiangping Wu
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| Open AccessCardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling
- Raymond W. Wong
- , Clifford A. Lingwood
- & Alan Cochrane
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| Open AccessRab-GTPase binding effector protein 2 (RABEP2) is a primed substrate for Glycogen Synthase kinase-3 (GSK3)
- Lisa Logie
- , Lidy Van Aalten
- & Calum Sutherland
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| Open AccessCK2 modulates adipocyte insulin-signaling and is up-regulated in human obesity
- Christian Borgo
- , Gabriella Milan
- & Roberto Vettor
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| Open AccessA switch in nucleotide affinity governs activation of the Src and Tec family kinases
- Freia von Raußendorf
- , Anita de Ruiter
- & Thomas A. Leonard
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| Open AccessA Ser75-to-Asp phospho-mimicking mutation in Src accelerates ageing-related loss of retinal ganglion cells in mice
- Kenji Kashiwagi
- , Sadahiro Ito
- & Goro Kato
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| Open AccessProtein-lysine methyltransferases G9a and GLP1 promote responses to DNA damage
- Vasudeva Ginjala
- , Lizahira Rodriguez-Colon
- & Shridar Ganesan
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| Open AccessFunctional interplay between the transcription factors USF1 and PDX-1 and protein kinase CK2 in pancreatic β-cells
- Sarah Spohrer
- , Rebecca Groß
- & Claudia Götz
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| Open AccessmTORC1 suppresses PIM3 expression via miR-33 encoded by the SREBP loci
- Ilana Kelsey
- , Marie Zbinden
- & Brendan D. Manning
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| Open AccessAssociation of protein kinase CK2 inhibition with cellular radiosensitivity of non-small cell lung cancer
- Qianwen Li
- , Ke Li
- & Gang Wu
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| Open AccessNew Insights into PI3K Inhibitor Design using X-ray Structures of PI3Kα Complexed with a Potent Lead Compound
- Xiuyan Yang
- , Xi Zhang
- & Jian Zhang
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| Open AccessThe antimalarial activity of the pantothenamide α-PanAm is via inhibition of pantothenate phosphorylation
- Joy E. Chiu
- , Jose Thekkiniath
- & Choukri Ben Mamoun
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| Open AccessUp-regulation of casein kinase 1ε is involved in tau pathogenesis in Alzheimer’s disease
- Caoyi Chen
- , Jianlan Gu
- & Fei Liu
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| Open AccessIdentification of PTPN1 as a novel negative regulator of the JNK MAPK pathway using a synthetic screening for pathway-specific phosphatases
- Jiyoung Moon
- , Jain Ha
- & Sang-Hyun Park
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| Open Access6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury
- C. Delehouzé
- , S. Leverrier-Penna
- & S. Bach
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| Open AccessStructural and functional insights into the periplasmic detector domain of the GacS histidine kinase controlling biofilm formation in Pseudomonas aeruginosa
- Ahmad Ali-Ahmad
- , Firas Fadel
- & Florence Vincent
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| Open AccessMAPK1 of Leishmania donovani interacts and phosphorylates HSP70 and HSP90 subunits of foldosome complex
- Pavneet Kaur
- , Mansi Garg
- & Neena Goyal
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| Open AccessExpression and characterisation of a Sarcoptes scabiei protein tyrosine kinase as a potential antigen for scabies diagnosis
- Nengxing Shen
- , Ran He
- & Guangyou Yang
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| Open AccessSrc-mediated tyrosine phosphorylation of Protein Kinase D2 at focal adhesions regulates cell adhesion
- Nisha Durand
- , Ligia I. Bastea
- & Peter Storz
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| Open AccessIRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation
- Gina Dörpholz
- , Arunima Murgai
- & Petra Knaus