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| Open AccessIdentification and structural characterization of small molecule inhibitors of PINK1
- Shafqat Rasool
- , Tara Shomali
- & Jean-François Trempe
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| Open AccessA Cre-dependent reporter mouse for quantitative real-time imaging of protein kinase A activity dynamics
- Elizabeth I. Tilden
- , Aditi Maduskar
- & Yao Chen
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| Open AccessEffect of histidine protonation state on ligand binding at the ATP-binding site of human protein kinase CK2
- Maria Winiewska-Szajewska
- , Daniel Paprocki
- & Jarosław Poznański
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| Open AccessValproate regulates inositol synthesis by reducing expression of myo-inositol-3-phosphate synthase
- Kendall C. Case
- , Rachel J. Beltman
- & Miriam L. Greenberg
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| Open AccessMechanism of TNFα-induced downregulation of salt-inducible kinase 2 in adipocytes
- Magdaléna Vaváková
- , Kaisa Hofwimmer
- & Olga Göransson
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| Open AccessCaMKII regulates the proteins TPM1 and MYOM2 and promotes diacetylmorphine-induced abnormal cardiac rhythms
- Min Ji
- , Liping Su
- & Hongwei Pu
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| Open AccessPan-kinome of Legionella expanded by a bioinformatics survey
- Marianna Krysińska
- , Bartosz Baranowski
- & Marcin Gradowski
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| Open AccessCaMKII regulates neuromuscular activity and survival of the human blood fluke Schistosoma mansoni
- Natasha L. Hirst
- , Scott P. Lawton
- & Anthony J. Walker
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| Open AccessProteomic consequences of TDA1 deficiency in Saccharomyces cerevisiae: Protein kinase Tda1 is essential for Hxk1 and Hxk2 serine 15 phosphorylation
- Henry Müller
- , Antoine Lesur
- & Karina Kettner
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| Open AccessXanthohumol exerts anti-inflammatory effects in an in vitro model of mechanically stimulated cementoblasts
- Christian Niederau
- , Shruti Bhargava
- & Michael Wolf
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| Open AccessDissecting the roles of Haspin and VRK1 in histone H3 phosphorylation during mitosis
- Tyrell N. Cartwright
- , Rebecca J. Harris
- & Jonathan M. G. Higgins
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| Open AccessSH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding
- Ben F. Brian IV
- , Frances V. Sjaastad
- & Tanya S. Freedman
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| Open AccessRhoifolin from Plumula Nelumbinis exhibits anti-cancer effects in pancreatic cancer via AKT/JNK signaling pathways
- Bingxin Zheng
- , Yixin Zheng
- & Baodong Zheng
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| Open AccessHigh-throughput translational profiling with riboPLATE-seq
- Jordan B. Metz
- , Nicholas J. Hornstein
- & Peter A. Sims
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| Open AccessMechanism of kinetin-induced death of Vicia faba ssp. minor root cortex cells
- Andrzej Kaźmierczak
- , Anita Kunikowska
- & Andrzej Kornaś
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| Open AccessASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes
- Saki Takayanagi
- , Kengo Watanabe
- & Hidenori Ichijo
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| Open AccessSalt inducible kinases 2 and 3 are required for thymic T cell development
- Meriam Nefla
- , Nicola J. Darling
- & J. Simon C. Arthur
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| Open AccessIncreased oxidative stress contributes to enhance brain amyloidogenesis and blunts energy metabolism in sucrose-fed rat: effect of AMPK activation
- Luz Camacho-Castillo
- , Bryan V. Phillips-Farfán
- & Karla Carvajal
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| Open AccessMechanisms and consequences of casein kinase II and ankyrin-3 regulation of the epithelial Na+ channel
- Tarek Mohamed Abd El-Aziz
- , Antonio G. Soares
- & Jonathan M. Berman
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| Open AccessUnderstanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10
- Xiang Wang
- , Elvira Negrou
- & Anastasia G. Henry
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| Open AccessHSP-90/kinase complexes are stabilized by the large PPIase FKB-6
- Siyuan Sima
- , Katalin Barkovits
- & Klaus Richter
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| Open Accesstrans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway
- Yusuke Hirata
- , Miki Takahashi
- & Atsushi Matsuzawa
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| Open AccessGeneration of a chemical genetic model for JAK3
- Judit Remenyi
- , Rangeetha Jayaprakash Naik
- & J. Simon C. Arthur
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| Open AccessA survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics
- Jessica Knox
- , Nicolas Joly
- & Peter J. Roy
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| Open AccessNetrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling
- Ahmad Abdullah
- , Carl Herdenberg
- & Håkan Hedman
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| Open AccessTiliroside as a CAXII inhibitor suppresses liver cancer development and modulates E2Fs/Caspase-3 axis
- Rui Han
- , Hongxing Yang
- & Lizhu Lin
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Article
| Open AccessInhibition of ERK 1/2 kinases prevents tendon matrix breakdown
- Ulrich Blache
- , Stefania L. Wunderli
- & Jess G. Snedeker
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| Open AccessRegulation of cardiomyocyte DNA damage and cell death by the type 2A protein phosphatase regulatory protein alpha4
- Jonathan Cowan
- , Michael R. Longman
- & Andrew K. Snabaitis
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| Open AccessMaximized quantitative phosphoproteomics allows high confidence dissection of the DNA damage signaling network
- Vitor Marcel Faca
- , Ethan J. Sanford
- & Marcus B. Smolka
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| Open AccessDissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells
- Thor C. Møller
- , Mie F. Pedersen
- & Hans Bräuner-Osborne
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| Open AccessBisindolylpyrrole triggers transient mitochondrial permeability transitions to cause apoptosis in a VDAC1/2 and cyclophilin D-dependent manner via the ANT-associated pore
- Masami Koushi
- , Yasunori Aoyama
- & Rei Asakai
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| Open AccessJNK signaling regulates oviposition in the malaria vector Anopheles gambiae
- Matthew J. Peirce
- , Sara N. Mitchell
- & Flaminia Catteruccia
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| Open AccessSelective dysregulation of ROCK2 activity promotes aberrant transcriptional networks in ABC diffuse large B-cell lymphoma
- Edd Ricker
- , Akanksha Verma
- & Alessandra B. Pernis
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| Open AccessSIRT3 and GCN5L regulation of NADP+- and NADPH-driven reactions of mitochondrial isocitrate dehydrogenase IDH2
- Katarína Smolková
- , Jitka Špačková
- & Petr Ježek
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| Open AccessMarkers of tissue damage and inflammation after robotic and abdominal hysterectomy in early endometrial cancer: a randomised controlled trial
- Evelyn Serreyn Lundin
- , Ninnie Borendal Wodlin
- & Preben Kjølhede
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| Open AccessDifferential kinase activity of ACVR1 G328V and R206H mutations with implications to possible TβRI cross-talk in diffuse intrinsic pontine glioma
- Hongnan Cao
- , Miao Jin
- & Jeffrey Skolnick
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| Open AccessTransport and kinase activities of CbrA of Pseudomonas putida KT2440
- Larissa Wirtz
- , Michelle Eder
- & Heinrich Jung
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| Open Accesstrans-Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop
- Yusuke Hirata
- , Aya Inoue
- & Atsushi Matsuzawa
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| Open AccessActivation of RSK by phosphomimetic substitution in the activation loop is prevented by structural constraints
- Desiana Somale
- , Giovanna Di Nardo
- & Paolo Armando Gagliardi
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| Open AccessEvaluation of binding and inhibition mechanism of dietary phytochemicals with sphingosine kinase 1: Towards targeted anticancer therapy
- Preeti Gupta
- , Taj Mohammad
- & Md. Imtaiyaz Hassan
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| Open AccessThe protein tyrosine kinase SYK regulates the alternative p38 activation in liver during acute liver inflammation
- Bo-Ram Bang
- , Kyung Ho Han
- & Young Jun Kang
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| Open AccessDDR1 autophosphorylation is a result of aggregation into dense clusters
- David S. Corcoran
- , Victoria Juskaite
- & Birgit Leitinger
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| Open AccessFunctional tunability from a distance: Rheostat positions influence allosteric coupling between two distant binding sites
- Tiffany Wu
- , Liskin Swint-Kruse
- & Aron W. Fenton
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| Open AccessUnderstanding allosteric interactions in hMLKL protein that modulate necroptosis and its inhibition
- Nupur Bansal
- , Simone Sciabola
- & Govinda Bhisetti
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| Open AccessDiscovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors
- Irina Kufareva
- , Benoit Bestgen
- & Ruben Abagyan
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| Open AccessA cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
- Pooja Sharma
- , Robert Mahen
- & Ashok R. Venkitaraman
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| Open AccessIntracerebroventricular injection of ouabain causes mania-like behavior in mice through D2 receptor activation
- Alexander Lopachev
- , Anna Volnova
- & Raul Gainetdinov
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| Open AccessDownregulation of GRK5 hampers the migration of breast cancer cells
- Ann-Katrin Sommer
- , Mathias Falcenberg
- & Andreas Roidl
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| Open AccessStructural analysis of fungal pathogenicity-related casein kinase α subunit, Cka1, in the human fungal pathogen Cryptococcus neoformans
- Belinda X. Ong
- , Youngki Yoo
- & Hyun-Soo Cho