Innate immunity articles within Nature Reviews Endocrinology

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  • Review Article |

    Adipose tissue inflammation is an adaptive response to overnutrition in the early stages of obesity, but later becomes maladaptive. Here, Reilly and Saltiel review the cellular and molecular mechanisms of obesity-induced inflammation in adipose tissue and discuss potential therapeutic approaches.

    • Shannon M. Reilly
    •  & Alan R. Saltiel

  • Review Article |

    Obesity is associated with inflammatory responses in the brain, particularly the hypothalamus, which could open up new therapeutic targets. This Review will discuss the innate immune response in the hypothalamic neuron–glial circuit to obesity and associated metabolic disorders and propose corresponding strategies for treating obesity.

    • Stefanie Kälin
    • , Frank L. Heppner
    •  & Chun-Xia Yi

  • Opinion |

    Emerging data suggest a role for autoimmunity in type 2 diabetes mellitus (T2DM). In this Perspectives, the authors discuss the nature of the immune response in diabetes mellitus and the evidence for an autoimmune component in T2DM and obesity.

    • Lício A. Velloso
    • , Decio L. Eizirik
    •  & Miriam Cnop

  • News & Views |

    Two trials have assessed the use of canakinumab and anakinra in patients with new-onset type 1 diabetes mellitus (T1DM). Although fairly safe, the drugs were not efficacious in terms of halting the decline in β-cell function. Is this the end of the line for targeting IL-1 in T1DM?

    • F. Susan Wong
    •  & Li Wen

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