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Immunotherapy for T1DM—targeting innate immunity

Nature Reviews Endocrinology volume 9, pages 384–385 (2013)Cite this article

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Two trials have assessed the use of canakinumab and anakinra in patients with new-onset type 1 diabetes mellitus (T1DM). Although fairly safe, the drugs were not efficacious in terms of halting the decline in β-cell function. Is this the end of the line for targeting IL-1 in T1DM?

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Figure 1: IL-1 secretion and action on islet β cells.

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Authors and Affiliations

  1. Diabetes Research Group, Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, UK

    F. Susan Wong

  2. Department of Medicine, Section of Endocrinology, Yale School of Medicine, 333 Cedar Street, New Haven, 06520, CT, USA

    Li Wen

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  1. F. Susan Wong
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  2. Li Wen
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Correspondence to F. Susan Wong.

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The authors declare no competing financial interests.

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Wong, F., Wen, L. Immunotherapy for T1DM—targeting innate immunity. Nat Rev Endocrinol 9, 384–385 (2013). https://doi.org/10.1038/nrendo.2013.103

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