Haemic and immune systems

The haemic and immune systems are the systems of organs and tissues, including the bone marrow, spleen, thymus and lymph nodes, involved in the production of cellular blood components.

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Latest Research and Reviews

  • Research |

    Single-cell transcriptomics reveals immune and stromal compartment remodeling, including the enrichment of unique populations of epithelial cells and CD4+ T cells, in asthmatic lungs

    • Felipe A. Vieira Braga
    • , Gozde Kar
    • , Marijn Berg
    • , Orestes A. Carpaij
    • , Krzysztof Polanski
    • , Lukas M. Simon
    • , Sharon Brouwer
    • , Tomás Gomes
    • , Laura Hesse
    • , Jian Jiang
    • , Eirini S. Fasouli
    • , Mirjana Efremova
    • , Roser Vento-Tormo
    • , Carlos Talavera-López
    • , Marnix R. Jonker
    • , Karen Affleck
    • , Subarna Palit
    • , Paulina M. Strzelecka
    • , Helen V. Firth
    • , Krishnaa T. Mahbubani
    • , Ana Cvejic
    • , Kerstin B. Meyer
    • , Kourosh Saeb-Parsy
    • , Marjan Luinge
    • , Corry-Anke Brandsma
    • , Wim Timens
    • , Ilias Angelidis
    • , Maximilian Strunz
    • , Gerard H. Koppelman
    • , Antoon J. van Oosterhout
    • , Herbert B. Schiller
    • , Fabian J. Theis
    • , Maarten van den Berge
    • , Martijn C. Nawijn
    •  & Sarah A. Teichmann
  • Research |

    Treg cells are essential for self-tolerance. Huseby and colleagues identify multiple de facto Treg cell self-peptides and show that Treg cells are exported from the thymus within a defined postnatal developmental window that is controlled by their increased negative selection.

    • Brian D. Stadinski
    • , Sydney J. Blevins
    • , Nicholas A. Spidale
    • , Brian R. Duke
    • , Priya G. Huseby
    • , Lawrence J. Stern
    •  & Eric S. Huseby
  • Research |

    • Andrew C. Scott
    • , Friederike Dündar
    • , Paul Zumbo
    • , Smita S. Chandran
    • , Christopher A. Klebanoff
    • , Mojdeh Shakiba
    • , Prerak Trivedi
    • , Laura Menocal
    • , Heather Appleby
    • , Steven J. Camara
    • , Dmitriy Zamarin
    • , Tyler Walther
    • , Alexandra C. Snyder
    • , Matthew R. Femia
    • , Elizabeth A. Comen
    • , Hannah Y. Wen
    • , Matthew D. Hellmann
    • , Niroshana Anandasabapathy
    • , Yong Liu
    • , Nasser K. Altorki
    • , Peter Lauer
    • , Olivier Levy
    • , Michael Glickman
    • , Jonathan Kaye
    • , Doron Betel
    • , Mary Philip
    •  & Andrea Schietinger
    Nature, 1-8
  • Research |

    Long-lived, self-renewing ‘progenitor-like’ CD8+ T cells can arise during chronic viral infection or in cancer. Wu and colleagues identify the transcription factor TOX as essential to endow ‘stemness’ and long-term persistence in the face of chronic infection.

    • Chen Yao
    • , Hong-Wei Sun
    • , Neal E. Lacey
    • , Yun Ji
    • , E. Ashley Moseman
    • , Han-Yu Shih
    • , Elisabeth F. Heuston
    • , Martha Kirby
    • , Stacie Anderson
    • , Jun Cheng
    • , Omar Khan
    • , Robin Handon
    • , Julie Reilley
    • , Jessica Fioravanti
    • , Jinhui Hu
    • , Selamawit Gossa
    • , E. John Wherry
    • , Luca Gattinoni
    • , Dorian B. McGavern
    • , John J. O’Shea
    • , Pamela L. Schwartzberg
    •  & Tuoqi Wu
    Nature Immunology 20, 890-901
  • Research |

    • Omar Khan
    • , Josephine R. Giles
    • , Sierra McDonald
    • , Sasikanth Manne
    • , Shin Foong Ngiow
    • , Kunal P. Patel
    • , Michael T. Werner
    • , Alexander C. Huang
    • , Katherine A. Alexander
    • , Jennifer E. Wu
    • , John Attanasio
    • , Patrick Yan
    • , Sangeeth M. George
    • , Bertram Bengsch
    • , Ryan P. Staupe
    • , Greg Donahue
    • , Wei Xu
    • , Ravi K. Amaravadi
    • , Xiaowei Xu
    • , Giorgos C. Karakousis
    • , Tara C. Mitchell
    • , Lynn M. Schuchter
    • , Jonathan Kaye
    • , Shelley L. Berger
    •  & E. John Wherry
    Nature, 1-13

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