Immune system

Definition

The immune system is a complex network of cells, tissues and organs that work together to protect the body from harmful substances and organisms and defend against disease. The immune system can be classified into distinct responses, such as innate immunity and adaptive immunity, or humoral immunity and cell-mediated immunity.

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Latest Research and Reviews

  • Research |

    The authors devise an algorithm that can cluster T cell receptor (TCR) sequences sharing the same specificity, predict the HLA restriction of these TCR clusters on the basis of subjects’ genotypes and help to identify specific peptide major histocompatibility complex ligands.

    • Jacob Glanville
    • , Huang Huang
    • , Allison Nau
    • , Olivia Hatton
    • , Lisa E. Wagar
    • , Florian Rubelt
    • , Xuhuai Ji
    • , Arnold Han
    • , Sheri M. Krams
    • , Christina Pettus
    • , Nikhil Haas
    • , Cecilia S. Lindestam Arlehamn
    • , Alessandro Sette
    • , Scott D. Boyd
    • , Thomas J. Scriba
    • , Olivia M. Martinez
    •  & Mark M. Davis
  • Research | | open

    Axl is a TAM receptor that can inhibit Toll-like receptor (TLR) -induced pro-inflammatory production by dendritic cells (DC). Here the authors show that miR-34a targets Axl to control CD1c+ DC activity in mice, and that miR-34a-deficient mice are resistant to collagen-induced arthritis, whereas DCs from patients with rheumatoid arthritis have high levels of miR- 34a.

    • Mariola Kurowska-Stolarska
    • , Stefano Alivernini
    • , Emma Garcia Melchor
    • , Aziza Elmesmari
    • , Barbara Tolusso
    • , Clare Tange
    • , Luca Petricca
    • , Derek S. Gilchrist
    • , Gabriele Di Sante
    • , Chantal Keijzer
    • , Lynn Stewart
    • , Clara Di Mario
    • , Vicky Morrison
    • , James M. Brewer
    • , Duncan Porter
    • , Simon Milling
    • , Ronald D. Baxter
    • , David McCarey
    • , Elisa Gremese
    • , Greg Lemke
    • , Gianfranco Ferraccioli
    • , Charles McSharry
    •  & Iain B. McInnes
  • Research | | open

    IL-10+ Tr1 cells, which do not express stable Foxp3 like conventional Treg cells, are associated with various diseases, but little is known about how their differentiation and function are regulated. Here the authors show that ITK is a central TCR signalling effector of the differentiation and function of Tr1 cells.

    • Weishan Huang
    • , Sabrina Solouki
    • , Nicholas Koylass
    • , Song-Guo Zheng
    •  & Avery August
  • Research |

    Prenatal immune suppression is regulated by fetal arginase-2-expressing dendritic cells which respond normally to toll-like receptor stimulation but, in contrast to adult dendritic cells, induce regulatory T cells and repress TNF-α secretion by effector T cells.

    • Naomi McGovern
    • , Amanda Shin
    • , Gillian Low
    • , Donovan Low
    • , Kaibo Duan
    • , Leong Jing Yao
    • , Rasha Msallam
    • , Ivy Low
    • , Nurhidaya Binte Shadan
    • , Hermi R Sumatoh
    • , Erin Soon
    • , Josephine Lum
    • , Esther Mok
    • , Sandra Hubert
    • , Peter See
    • , Edwin Huang Kunxiang
    • , Yie Hou Lee
    • , Baptiste Janela
    • , Mahesh Choolani
    • , Citra Nurfarah Zaini Mattar
    • , Yiping Fan
    • , Tony Kiat Hon Lim
    • , Dedrick Kok Hong
    • , Ker-Kan Tan
    • , John Kit Chung Tam
    • , Christopher Schuster
    • , Adelheid Elbe-Bürger
    • , Xiao-nong Wang
    • , Venetia Bigley
    • , Matthew Collin
    • , Muzlifah Haniffa
    • , Andreas Schlitzer
    • , Michael Poidinger
    • , Salvatore Albani
    • , Anis Larbi
    • , Evan W Newell
    • , Jerry Kok Yen Chan
    •  & Florent Ginhoux
  • Research | | open

    The protein kinase Lkb1 has been shown to limit conventional T cell activation and pro-inflammatory functions. Here the authors show that Lkb1 also maintains Foxp3 expression and suppressive function in regulatory T (Treg) cells, and that Treg-specific Lkb1-deficient mice develop fatal autoimmune disease.

    • Di Wu
    • , Yuechen Luo
    • , Wei Guo
    • , Qing Niu
    • , Ting Xue
    • , Fei Yang
    • , Xiaolei Sun
    • , Song Chen
    • , Yuanyuan Liu
    • , Jingru Liu
    • , Zhina Sun
    • , Chunxiao Zhao
    • , Huifang Huang
    • , Fang Liao
    • , Zhongchao Han
    • , Dongming Zhou
    • , Yongguang Yang
    • , Guogang Xu
    • , Tao Cheng
    •  & Xiaoming Feng

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