Endometrial cancer articles within Nature

Featured

  • Article
    | Open Access

    We describe netrin-1 upregulation in a majority of human endometrial carcinomas and demonstrate that netrin-1 blockade, using the anti-netrin-1 antibody NP137, is effective both in a mouse model and in patients with endometrial carcinomas.

    • Philippe A. Cassier
    • , Raul Navaridas
    •  & Patrick Mehlen

  • Article
    | Open Access

    An integrative genomic analysis of several hundred endometrial carcinomas shows that a minority of tumour samples carry copy number alterations or TP53 mutations and many contain key cancer-related gene mutations, such as those involved in canonical pathways and chromatin remodelling; a reclassification of endometrial tumours into four distinct types is proposed, which may have an effect on patient treatment regimes.

    • Douglas A. Levine
    • , Gad Getz
    •  & Douglas A. Levine

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