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Article
| Open Access
High-resolution structural and functional deep brain imaging using adaptive optics three-photon microscopy
Three-photon microscopy in combination with adaptive optics-based aberration correction and ECG-triggered gating allows high-resolution imaging of neurons and astrocytes up to a depth of 1.4 mm in the mouse brain.
- Lina Streich
- , Juan Carlos Boffi
- & Robert Prevedel
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Brief Communication |
Rapid and efficient induction of functional astrocytes from human pluripotent stem cells
A simple transcription-factor-based protocol generates functional astrocytes rapidly and efficiently from human pluripotent stem cells.
- Isaac Canals
- , Aurélie Ginisty
- & Henrik Ahlenius
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Article |
Induction of myelinating oligodendrocytes in human cortical spheroids
A method for generating cortical spheroids from human pluripotent stem cells produces maturing oligodendrocytes that can myelinate axons and model myelin disease and drug effects.
- Mayur Madhavan
- , Zachary S. Nevin
- & Paul J. Tesar
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Methods in Brief |
Myelin quantification at nanoscale
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Research Highlights |
Microfetti: a fate-mapping system for microglia
A multicolor reporter mouse model enables monitoring of the fate and dynamics of microglia in health and disease.
- Kate Gao
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Correspondence |
In vivo imaging of oligodendrocytes with sulforhodamine 101
- Robert A Hill
- & Jaime Grutzendler
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Tools in Brief |
Myelination in arrays
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Research Highlights |
Magnificent myelin
Spectral confocal reflectance microscopy helps visualize myelinated axons in vivo without any labeling.
- Nina Vogt
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Article |
A culture system to study oligodendrocyte myelination processes using engineered nanofibers
Primary rat oligodendocytes were cultured in the presence of electron-spun nanofibers of varying sizes as a model to study myelination processes in the mammalian central nervous system. The authors study the role of fiber diameter on the initiation of concentric wrapping by oligodendrocytes.
- Seonok Lee
- , Michelle K Leach
- & Jonah R Chan
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This Month |
Paul Tesar
Pure oligodendrocyte populations can be made without cell sorting.
- Monya Baker
- & Paul Tesar
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Article |
Rapid and robust generation of functional oligodendrocyte progenitor cells from epiblast stem cells
Reported is the robust directed differentiation of mouse epiblast stem cells to oligodendrocyte precursor cells, which then differentiate into myelinating oligodendrocytes in vitro and in vivo. The system should prove useful for basic research and for drug screens.
- Fadi J Najm
- , Anita Zaremba
- & Paul J Tesar
Directed evolution of adeno-associated virus for efficient gene delivery to microglia