Gastrointestinal diseases articles within Nature

Featured

• Research Highlights | 30 November 2011

  Liver disease target

• News | 12 October 2011

  Liver-disease mutation corrected in human stem cells

  Patient-derived stem cells reprogrammed to become healthier.

  • Susan Young

• News | 27 September 2011

  Vaccine campaign to target deadly childhood diarrhoea

  Programme to guard against second-biggest killer of under-fives rolls out across Africa.

  • Declan Butler

• Letter | 14 September 2011

  Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

  • Claudia Günther
  • , Eva Martini
  •  & Christoph Becker

• Letter | 29 June 2011

  Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

  • Sayaka Sekiya
  •  & Atsushi Suzuki

• Review Article | 15 June 2011

  Genetics and pathogenesis of inflammatory bowel disease

  • Bernard Khor
  • , Agnès Gardet
  •  & Ramnik J. Xavier

• Review Article | 15 June 2011

  Intestinal homeostasis and its breakdown in inflammatory bowel disease

  • Kevin J. Maloy
  •  & Fiona Powrie

• Outlook | 08 June 2011

  Hepatitis C

  • Herb Brody

• Outlook | 08 June 2011

  Perspective: Miles to go before we sleep

  New drugs are generating much excitement, but a cure for all will take generations of therapies, argues Charles Rice

  • Charles Rice

• Outlook | 08 June 2011

  Perspective: Recognizing resistance

  The hepatitis C virus is endemic among injection drug users, who could harbour treatment-resistant viruses. We need to adapt to this reality, says Diana Sylvestre

  • Diana Sylvestre

• Outlook | 08 June 2011

  Pharmacogenomics: Playing the odds

  Can doctors calculate a patient's chance of being cured by searching their DNA? Hepatitis C researchers are starting to make this a reality.

  • Amy Maxmen

• Outlook | 08 June 2011

  Introduction: A smouldering public-health crisis

  Long overshadowed by HIV, the hepatitis C virus is starting to take its toll. And the heat is on to find and treat those affected.

  • Lauren Gravitz

• Outlook | 08 June 2011

  Global health: A uniquely Egyptian epidemic

  Egypt has the highest prevalence of hepatitis C worldwide. And the epidemic will soon peak. Prevention demands political will, ample funding and a change in mindset.

  • Mohammed Yahia

• Outlook | 08 June 2011

  Therapeutics: New drugs hit the target

  With two recently approved drugs and dozens more in the pipeline, hepatitis C treatment will improve over the next decade.

  • Jana Schlütter

• Outlook | 08 June 2011

  Vaccines: A moving target

  The hepatitis C virus has a set of cunning ways to evade immunity, but researchers are turning the immune system on it.

  • Michael Eisenstein

• Outlook | 08 June 2011

  Diagnostics: A testing journey

  Results ready in minutes and more efficacious drugs will help find and treat the hundreds of millions of carriers.

  • Sarah DeWeerdt

• Letter | 08 June 2011

  A genetically humanized mouse model for hepatitis C virus infection

  • Marcus Dorner
  • , Joshua A. Horwitz
  •  & Alexander Ploss

• News & Views | 30 March 2011

  The sound of silence

  There are various ways in which apparently 'silent' DNA mutations — those that don't result in a change in the encoded protein — have untoward consequences. A striking example has emerged in a study of Crohn's disease.

  • Laurence D. Hurst

• News & Views | 09 March 2011

  Context is key in the gut

  The vitamin-A metabolite retinoic acid normally favours immune tolerance in the gut. But in coeliac disease — an intestinal inflammatory disorder due to adverse reactivity to a dietary protein — it may do just the opposite. See Letter p.220

  • Craig L. Maynard
  •  & Casey T. Weaver

• News Explainer | 14 January 2011

  Is breast not best for babies?

  New evidence contradicts World Health Organization breastfeeding advice.

  • Natasha Gilbert

• News & Views | 27 October 2010

  Genomic evolution of metastasis

  Prognosis for patients with pancreatic cancer is bleak, often owing to late diagnosis. The estimate that at least 15 years pass from tumour initiation to malignancy offers hope for early detection and prevention. See Letters p.1109 & p.1114

  • E. Georg Luebeck

• News & Views | 04 August 2010

  Genes, viruses and microbes

  Variations in several genes can increase an individual's susceptibility to complex disorders. But what tips the balance to cause the full-blown disease? For Crohn's disease, viruses could provide part of the answer.

  • Alison Simmons

• Research Highlights | 30 June 2010

  Immunology: Gene plus virus

• News & Views | 05 May 2010

  An unsuspected drug target

  Infection with hepatitis C is one of the main causes of liver disease, yet there are no broadly effective treatments. Discovery of a potent inhibitor of this virus shows that researchers must think outside the box.

  • Catherine L. Murray
  •  & Charles M. Rice