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Hepatitis C

An unsuspected drug target

Infection with hepatitis C is one of the main causes of liver disease, yet there are no broadly effective treatments. Discovery of a potent inhibitor of this virus shows that researchers must think outside the box.

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Figure 1: Life cycle of the hepatitis C virus (HCV).

References

  1. Gao, M. et al. Nature 465, 96–100 (2010).

    Article  ADS  CAS  Google Scholar 

  2. Ge, D. et al. Nature 461, 399–401 (2009).

    Article  ADS  CAS  Google Scholar 

  3. Suppiah, V. et al. Nature Genet. 41, 1100–1104 (2009).

    Article  CAS  Google Scholar 

  4. Tanaka, Y. et al. Nature Genet. 41, 1105–1109 (2009).

    Article  CAS  Google Scholar 

  5. De Francesco, R. & Migliaccio, G. Nature 436, 953–960 (2005).

    Article  ADS  CAS  Google Scholar 

  6. Kwong, A. D., McNair, L., Jacobson, I. & George, S. Curr. Opin. Pharmacol. 8, 522–531 (2008).

    Article  CAS  Google Scholar 

  7. Lemm, J. A. et al. J. Virol. 84, 482–491 (2010).

    Article  CAS  Google Scholar 

  8. Tellinghuisen, T. L., Foss, K. L. & Treadaway, J. PLoS Pathog. 4, e1000032 (2008).

    Article  Google Scholar 

  9. Appel, N. et al. PLoS Pathog. 4, e1000035 (2008).

    Article  Google Scholar 

  10. Tellinghuisen, T. L., Marcotrigiano, J. & Rice, C. M. Nature 435, 374–379 (2005).

    Article  ADS  CAS  Google Scholar 

  11. Love, R. A., Brodsky, O., Hickey, M. J., Wells, P. A. & Cronin, C. N. J. Virol. 83, 4395–4403 (2009).

    Article  CAS  Google Scholar 

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Murray, C., Rice, C. An unsuspected drug target. Nature 465, 43–44 (2010). https://doi.org/10.1038/465042a

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