Featured
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Letter |
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
A combination of TGFβ inhibition and checkpoint-inhibition therapy provokes a potent cytotoxic response against metastatic tumours derived from colorectal cancers in mice.
- Daniele V. F. Tauriello
- , Sergio Palomo-Ponce
- & Eduard Batlle
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Article |
Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes
Oncogenic dosage variation along distinct evolutionary routes defines fundamental aspects of pancreatic cancer biology and phenotypic diversification.
- Sebastian Mueller
- , Thomas Engleitner
- & Roland Rad
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Letter |
Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer
The analysis of T-cell antigens in long-term survivors of pancreatic ductal adenocarcinoma suggests that neoantigen immunogenicity and quality, not purely quantity, correlate with survival.
- Vinod P. Balachandran
- , Marta Łuksza
- & Steven D. Leach
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Brief Communications Arising |
Upholding a role for EMT in pancreatic cancer metastasis
- Nicole M. Aiello
- , Thomas Brabletz
- & Ben Z. Stanger
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Article |
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
Exosomes improve the delivery of siRNA to mutant KRAS in the pancreatic tumours and bypass immune clearance better than artificial liposomes, probably owing to enhanced macropinocytocis and presence of CD47 on exosomes, respectively.
- Sushrut Kamerkar
- , Valerie S. LeBleu
- & Raghu Kalluri
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Article |
A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer
Ablation of Lgr5+ cancer stem cells does not result in regression of primary colorectal tumours, but prevents the formation and maintenance of metastasis in the liver.
- Felipe de Sousa e Melo
- , Antonina V. Kurtova
- & Frederic J. de Sauvage
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Article |
Visualization and targeting of LGR5+ human colon cancer stem cells
LGR5+ cells in human colorectal cancer tissue xenografted into mice act as cancer stem cells, and differentiated cancer cells can revert to cancer stem cells and express LGR5 after ablation of existing LGR5+ cells.
- Mariko Shimokawa
- , Yuki Ohta
- & Toshiro Sato
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Letter |
Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer
Depletion of malic enzyme 3 in pancreatic cancer cells that have a deletion of the gene for malic enzyme 2 selectively kills the cells, suggesting that the enzyme might represent a therapeutic target for this subset of cancers.
- Prasenjit Dey
- , Joelle Baddour
- & Ronald A. DePinho
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Article
| Open AccessIntegrated genomic characterization of oesophageal carcinoma
The Cancer Genome Atlas Research Network report integrated genomic and molecular analyses of 164 squamous cell carcinomas and adenocarcinomas of the oesophagus; they find genomic and molecular features that differentiate squamous and adenocarcinomas of the oesophagus, and strong similarities between oesophageal adenocarcinomas and the chromosomally unstable variant of gastric adenocarcinoma, suggesting that gastroesophageal adenocarcinoma is a single disease entity.
- Jihun Kim
- , Reanne Bowlby
- & Jiashan Zhang
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Letter |
A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns
Pancreatic cancer is not caused by a specific series of genetic alterations that occur sequentially but by one, or few, catastrophic events that result in simultaneous oncogenic genetic rearrangements, giving rise to highly aggressive tumours.
- Faiyaz Notta
- , Michelle Chan-Seng-Yue
- & Steven Gallinger
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Letter |
The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression
A study of pancreatic ductal adenocarcinoma shows that cancer cell proliferation is associated with increased expression of proteins that control programmed necrotic cell death and suppress the adaptive immune system.
- Lena Seifert
- , Gregor Werba
- & George Miller
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Letter |
NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis
Non-alcoholic fatty liver disease (NAFLD) is shown to promote hepatocellular carcinoma through the generation of linoleic acid, disruption of mitochondrial function and selective loss of CD4+ T cells, leading to impaired anti-tumour immunity.
- Chi Ma
- , Aparna H. Kesarwala
- & Tim F. Greten
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Article |
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
A high-fat diet increases the number of intestinal stem cells in mammals, both in vivo and in intestinal organoids; a pathway that involves PPAR-δ confers organoid-initiating capacity to non-stem cells and induces them to form in vivo tumours after loss of the Apc tumour suppressor.
- Semir Beyaz
- , Miyeko D. Mana
- & Ömer H. Yilmaz
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Article |
Genomic analyses identify molecular subtypes of pancreatic cancer
An integrated genomic analysis of 456 human pancreatic ductal adenocarcinomas identifies four subtypes defined by transcriptional expression profiles and show that these are associated with distinct histopathological characteristics and differential prognosis.
- Peter Bailey
- , David K. Chang
- & Sean M. Grimmond
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Letter |
Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function
Antibody-mediated inhibition of R-spondin-3 in colorectal tumours decreases tumour growth and promotes differentiation—these effects are associated with a decrease in expression of genes associated with stem-cell function.
- Elaine E. Storm
- , Steffen Durinck
- & Frederic J. de Sauvage
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Letter |
Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism
The MiT/TFE family of transcription factors is found to coordinate constitutive activation of autophagy and lysosome biogenesis to drive the metabolic programming and malignant growth of pancreatic cancer.
- Rushika M. Perera
- , Svetlana Stoykova
- & Nabeel Bardeesy
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Article |
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Glypican-1 identifies cancer exosomes and serves as a biomarker for detection of early pancreatic cancer in patients and mouse models of the disease; the findings may enable early and non-invasive identification, and prevention of malignant cancer.
- Sonia A. Melo
- , Linda B. Luecke
- & Raghu Kalluri
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Letter |
Putative cis-regulatory drivers in colorectal cancer
Examination of allele-specific expression identifies 71 genes with excess somatic cis-regulatory effects in colorectal cancer (CRC), and 1,693 and 948 expression quantitative trait loci (eQTLs) in normal samples and tumours, respectively (with 36% of tumour eQTLs exclusive to CRC); tumour-specific eQTLs are more enriched for low CRC genome-wide association study P values and accumulate more somatic mutations than shared eQTLs, suggesting a role as germline-derived cancer regulatory drivers.
- Halit Ongen
- , Claus L. Andersen
- & Emmanouil T. Dermitzakis
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Article
| Open AccessComprehensive molecular characterization of gastric adenocarcinoma
The Cancer Genome Atlas reports on molecular evaluation of 295 primary gastric adenocarcinomas and proposes a new classification of gastric cancers into 4 subtypes, which should help with clinical assessment and trials of targeted therapies.
- Adam J. Bass
- , Vesteinn Thorsson
- & Jia Liu
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Article |
Proteogenomic characterization of human colon and rectal cancer
Proteome analysis of The Cancer Genome Atlas (TCGA) colorectal cancer specimens reveals that DNA- or RNA-level measurements cannot reliably predict protein abundance, colorectal tumours can be separated into distinct proteotypes, and that copy number alterations drive mRNA abundance changes but few extend to protein-level changes.
- Bing Zhang
- , Jing Wang
- & R. Reid Townsend
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Letter |
Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer
Gain-of-function mutations in isocitrate dehydrogenase (IDH) are among the most common genetic alterations in intrahepatic cholangiocarcinoma (IHCC), a deadly cancer of the liver bile ducts; now mutant IDH is shown to block liver cell differentiation through the suppression of HNF-4α, a master regulator of hepatocyte identity and quiescence, leading to expansion of liver progenitor cells primed for progression to IHCC.
- Supriya K. Saha
- , Christine A. Parachoniak
- & Nabeel Bardeesy
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Letter |
Replication stress links structural and numerical cancer chromosomal instability
A mechanism to explain chromosomal instability (CIN) in colorectal cancer is demonstrated; three new CIN-suppressor genes (PIGN, MEX3C and ZNF516) encoded on chromosome 18q are identified, the loss of which leads to DNA replication stress, resulting in structural and numerical chromosome segregation errors, which are shown to be identical to phenotypes seen in CIN cells.
- Rebecca A. Burrell
- , Sarah E. McClelland
- & Charles Swanton
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Letter |
Restriction of intestinal stem cell expansion and the regenerative response by YAP
YAP has previously been identified as an oncogene that promotes cell growth, but now it is shown to restrict stem cell expansion during regeneration in the mouse intestine, suggesting that it may function as a tumour suppressor in colon cancer.
- Evan R. Barry
- , Teppei Morikawa
- & Fernando D. Camargo
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Letter |
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
In a mouse model of colorectal cancer, barrier deterioration results in adenoma invasion by microbial products that trigger tumour-elicited inflammation, which in turn drives IL-23-dependent tumour growth.
- Sergei I. Grivennikov
- , Kepeng Wang
- & Michael Karin
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Article |
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Exome sequencing and copy number analysis are used to define genomic aberrations in early sporadic pancreatic ductal adenocarcinoma; among the findings are mutations in genes involved in chromatin modification and DNA damage repair, and frequent and diverse somatic aberrations in genes known as embryonic regulators of axon guidance.
- Andrew V. Biankin
- , Nicola Waddell
- & Sean M. Grimmond
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Letter |
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
IL-22 is one of the factors that, although important for wound healing, also promote tumorigenesis; the regulation of IL-22BP, the IL-22 binding protein, via the NLRP3 and NLRP6 inflammasomes provides an unanticipated mechanism, controlling IL-22 and thereby the development of colon cancer.
- Samuel Huber
- , Nicola Gagliani
- & Richard A. Flavell
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Research Highlights |
Inflamed guts boost bad bacteria
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News |
E. coli strain linked to cancer in mice
DNA-damaging bacterium flourishes in the guts of mice with inflammatory bowel disease.
- Ewen Callaway
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Letter
| Open AccessRecurrent R-spondin fusions in colon cancer
Exomes, transcriptomes and copy-number alterations in a sample of more than 70 primary human colonic tumours were analysed in an attempt to characterize the genomic landscape; in addition to finding alterations in genes associated with commonly mutated signalling pathways, recurrent gene fusions involving R-spondin family members were also found to occur in approximately 10% of colonic tumours, revealing a potential new therapeutic target.
- Somasekar Seshagiri
- , Eric W. Stawiski
- & Frederic J. de Sauvage
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Article
| Open AccessComprehensive molecular characterization of human colon and rectal cancer
The Cancer Genome Atlas consortium reports on their genome-wide characterization of somatic alterations in colorectal cancer; in addition to revealing a remarkably consistent pattern of genomic alteration, with 24 genes being significantly mutated, the study identifies new targets for therapeutic intervention and suggests an important role for MYC-directed transcriptional activation and repression.
- Donna M. Muzny
- , Matthew N. Bainbridge
- & Elizabeth Thomson.
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Letter |
RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis
A new method allows the collection of circulating tumour cells (CTCs) despite their rarity; transcriptome sequencing of CTCs could allow identification of pathways involved in metastasis.
- Min Yu
- , David T. Ting
- & Daniel A. Haber
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Letter |
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
This work on colorectal cancer shows that secondary mutations in KRAS that confer resistance to panitumumab, an anti-EGFR monoclonal antibody, are already present when antibody treatment begins; the apparent inevitability of resistance suggests that combinations of drugs targeting at least two different oncogenic pathway will be needed for treatment.
- Luis A. Diaz Jr
- , Richard T. Williams
- & Bert Vogelstein
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Letter |
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
Molecular alterations in KRAS are associated with acquired resistance to anti-epidermal growth factor receptor (EGFR) treatment in colorectal cancer; resistant mutations can be identified in the blood of patients, months before clinical evidence of disease progression.
- Sandra Misale
- , Rona Yaeger
- & Alberto Bardelli
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Research Highlights |
A tumour's Kras behaviour
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Letter |
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
An in vivo transposon screen in a pancreatic cancer model identifies frequent inactivation of Usp9x; deletion of Usp9x cooperates with KrasG12D to accelerate rapidly pancreatic tumorigenesis in mice, validating their genetic interaction.
- Pedro A. Pérez-Mancera
- , Alistair G. Rust
- & David A. Tuveson
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Research Highlights |
Tumours yield to pressure relief
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News |
Mouse 'avatars' could aid pancreatic cancer therapy
Personalized mouse model may lead to tailored treatments for patients.
- Carina Dennis
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News & Views |
Primed for resistance
A drug for treating melanoma is ineffective in colorectal cancers that have the same causative mutation. Studies of how cells adapt to the drug reveal why this is so, and suggest combination therapies that may be more effective. See Letter p.100
- David B. Solit
- & Pasi A. Jänne
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Letter |
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
Inhibition of activated BRAF has been ineffective in colon cancers with the mutation; here, this is shown to be due to the feedback activation of the epidermal growth factor receptor (EGFR) in response to BRAF inhibition.
- Anirudh Prahallad
- , Chong Sun
- & René Bernards
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Letter |
DCC constrains tumour progression via its dependence receptor activity
A mouse model is developed in which the pro-apoptotic activity of DCC is silenced and the mice are more prone to intestinal tumour progression, giving insight into the role of DCC in human colorectal cancer.
- Marie Castets
- , Laura Broutier
- & Patrick Mehlen
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News & Views |
Final act of senescence
Damaged cells can initiate cancer. To avert this, faulty cells disable their own propagation by undergoing senescence. But for full protection against liver cancer, the senescent cells must be cleared by the immune system. See Letter p.547
- Manuel Serrano
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Letter |
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
- Tae-Won Kang
- , Tetyana Yevsa
- & Lars Zender
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Review Article |
Microenvironmental regulation of stem cells in intestinal homeostasis and cancer
- Jan Paul Medema
- & Louis Vermeulen
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Research Highlights |
Probing for pancreatic cancer
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Research Highlights |
Laying siege to cancer
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Research Highlights |
Stem-cell genes linked to relapse
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Research Highlights |
Hide no more, tumour
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News |
New lead on deadly pancreatic cancer
Mouse model reveals mechanism of potential therapy for lethal tumours.
- Alison Abbott
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Research Highlights |
Liver cancer lifeline found