Featured
-
-
Article
| Open Access
Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver
Structural changes mediated by advanced glycation end-products enhance extracellular matrix viscoelasticity, and that viscoelasticity can promote cancer progression in vivo, independent of stiffness.
- Weiguo Fan
- , Kolade Adebowale
- & Natalie J. Török
-
Article |
Liver tumour immune microenvironment subtypes and neutrophil heterogeneity
Tumour-associated neutrophil populations enriched in the myeloid-cell-enriched tumour immune microenvironment subtype are associated with unfavourable prognosis in humans and mice with liver cancer.
- Ruidong Xue
- , Qiming Zhang
- & Ning Zhang
-
Article |
Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis
Subpopulations of cytokine-producing and myofibroblastic hepatic stellate cells, identified by single-cell RNA sequencing, protect against or promote the development of hepatocellular carcinoma via high expression of hepatocyte growth factor or type I collagen, respectively..
- Aveline Filliol
- , Yoshinobu Saito
- & Robert F. Schwabe
-
Article |
The U1 spliceosomal RNA is recurrently mutated in multiple cancers
A highly recurrent A>C somatic mutation in U1 small nuclear RNA, which alters the splicing pattern of genes that include known drivers of cancer, is identified in several types of tumour.
- Shimin Shuai
- , Hiromichi Suzuki
- & Lincoln D. Stein
-
Letter |
Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma
A subtype of early-stage hepatocellular carcinoma characterized by disrupted cholesterol homeostasis and associated with a poor prognosis responds to treatment with the SOAT1 inhibitor avasimibe in a patient-derived xenograft mouse model.
- Ying Jiang
- , Aihua Sun
- & Zesong Li
-
Letter |
NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis
Non-alcoholic fatty liver disease (NAFLD) is shown to promote hepatocellular carcinoma through the generation of linoleic acid, disruption of mitochondrial function and selective loss of CD4+ T cells, leading to impaired anti-tumour immunity.
- Chi Ma
- , Aparna H. Kesarwala
- & Tim F. Greten
-
News & Views |
Final act of senescence
Damaged cells can initiate cancer. To avert this, faulty cells disable their own propagation by undergoing senescence. But for full protection against liver cancer, the senescent cells must be cleared by the immune system. See Letter p.547
- Manuel Serrano
-
Letter |
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
- Tae-Won Kang
- , Tetyana Yevsa
- & Lars Zender
-
Research Highlights |
Liver cancer lifeline found
Deep whole-genome analysis of 494 hepatocellular carcinomas