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Translational medicine

Primed for resistance

A drug for treating melanoma is ineffective in colorectal cancers that have the same causative mutation. Studies of how cells adapt to the drug reveal why this is so, and suggest combination therapies that may be more effective. See Letter p.100

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Figure 1: Intrinsic drug resistance in colorectal cancer cells.

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Correspondence to David B. Solit or Pasi A. Jänne.

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Solit, D., Jänne, P. Primed for resistance. Nature 483, 44–45 (2012). https://doi.org/10.1038/483044a

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