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| Open AccessBrain-actuated functional electrical stimulation elicits lasting arm motor recovery after stroke
Brain-computer interface (BCI) can improve motor skills on stroke patients. This study shows that BCI-controlled neuromuscular electrical stimulation therapy can cause cortical reorganization due to activation of efferent and afferent pathways, and this effect can be long lasting in a brain region specific manner.
- A. Biasiucci
- , R. Leeb
- & J. d. R. Millán
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Article
| Open AccessOptimization of the structural characteristics of CaO and its effective stabilization yield high-capacity CO2 sorbents
The economic operation of a carbon dioxide capture technique of calcium looping necessitates highly effective CaO-based CO2 sorbents. Here, the authors report a facile one-pot synthesis approach to yield highly effective, MgO-stabilized, CaO-based CO2 sorbents featuring highly porous multishelled morphologies.
- Muhammad Awais Naeem
- , Andac Armutlulu
- & Christoph R. Müller
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Article
| Open AccessEfficient and self-adaptive in-situ learning in multilayer memristor neural networks
Memristor-based neural networks hold promise for neuromorphic computing, yet large-scale experimental execution remains difficult. Here, Xia et al. create a multi-layer memristor neural network with in-situ machine learning and achieve competitive image classification accuracy on a standard dataset.
- Can Li
- , Daniel Belkin
- & Qiangfei Xia
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Article
| Open AccessSingle-breath-hold photoacoustic computed tomography of the breast
The current standard for breast cancer diagnostic is a mammogram; however, the sensitivity of mammography can be low in radiographically dense breasts. Here the authors develop a single-breath-hold photoacoustic computed tomography (SBH-PACT) system to reveal detailed angiographic structures in human breasts allowing the detection of higher blood vessel densities associated with tumors.
- Li Lin
- , Peng Hu
- & Lihong V. Wang
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Article
| Open AccessImplementation of multilayer perceptron network with highly uniform passive memristive crossbar circuits
Memristive devices used in neuromorphic computing typically need to be accessed using transistors, adding circuit complexity and size. In this work, the authors demonstrate a neural network using a transistor-free passive memristor crossbar array, offering potential circuit miniaturisation and energy savings.
- F. Merrikh Bayat
- , M. Prezioso
- & D. Strukov
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Article
| Open AccessSoft transparent graphene contact lens electrodes for conformal full-cornea recording of electroretinogram
The electrical response of the eye to optical stimulus is important in disease diagnosis but current electrodes used have limitations. Here, the authors report on the development of soft transparent graphene-based contact lens electrodes for electroretinogram recording and test the device in vivo.
- Rongkang Yin
- , Zheng Xu
- & Xiaojie Duan
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Article
| Open AccessThe global flood protection savings provided by coral reefs
Coral reefs provide significant coastal protection from storms but they have experienced significant losses. Here the authors show that the annual damages from flooding would double globally without reefs and they quantify where reefs provide the most protection to people and property.
- Michael W. Beck
- , Iñigo J. Losada
- & Felipe Fernández
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Article
| Open AccessEstimating geological CO2 storage security to deliver on climate mitigation
Carbon capture and storage can help reduce CO2 emissions but the confidence in geologic CO2 storage security is uncertain. Here the authors present a numerical programme to estimate leakage from wells and find that under appropriate regulation 98% of injected CO2 will be retained over 10,000 years.
- Juan Alcalde
- , Stephanie Flude
- & R. Stuart Haszeldine
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Article
| Open AccessSeamlessly fused digital-analogue reconfigurable computing using memristors
Conventional analogue and digital circuits are mixed at signal level yet remain technologically separate, adding complexity and cost. This work introduces a new design paradigm where the analogue and digital worlds are seamlessly fused via memristors, enabling electronics with reconfigurability.
- Alexantrou Serb
- , Ali Khiat
- & Themistoklis Prodromakis
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Article
| Open AccessFibrotic microtissue array to predict anti-fibrosis drug efficacy
A bottleneck in developing new anti-fibrosis therapies is the absence of suitable in vitro models that recapitulate key features of fibrogenesis. Here the authors develop a tissue-on-a-chip model of lung fibrosis and test the therapeutic efficacy of two recent FDA-approved drugs.
- Mohammadnabi Asmani
- , Sanjana Velumani
- & Ruogang Zhao
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Article
| Open AccessHigh temperature deformability of ductile flash-sintered ceramics via in-situ compression
Flash sintering allows for rapid ceramic processing, but the mechanical behavior of such ceramics remains poorly understood. Here, the authors compress micropillars of yttria stabilized zirconia to show flash sintering promotes outstanding plasticity.
- Jaehun Cho
- , Qiang Li
- & Xinghang Zhang
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Article
| Open AccessSeparation of current density and electric field domains caused by nonlinear electronic instabilities
The usefulness of metal-oxide memristors for memory and brain-inspired computing applications arises from their electronic instabilities, whose details remain limited. In this work, the authors analyze electronic decompositions in several metal oxides, providing new insights for device modeling.
- Suhas Kumar
- & R. Stanley Williams
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Article
| Open AccessDeep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arrays
Optical imaging and manipulation technologies cannot be easily integrated with electrical recordings due to generation of light-induced artifacts. Here the authors report the optimization of transparent graphene microelectrode fabrication to achieve artifact-free electrical recordings along with deep 2-photon imaging in vivo.
- Martin Thunemann
- , Yichen Lu
- & Duygu Kuzum
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Article
| Open AccessControlling the coherence of a diamond spin qubit through its strain environment
Silicon-vacancy centres in diamond are promising candidates as emitters in photonic quantum networks, but their coherence is degraded by large electron-phonon interactions. Sohn et al. demonstrate the use of strain to tune a silicon vacancy’s electronic structure and suppress phonon-mediated decoherence.
- Young-Ik Sohn
- , Srujan Meesala
- & Marko Lončar
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| Open AccessNanoparticle-templated nanofiltration membranes for ultrahigh performance desalination
Nanofiltration membranes are important for water desalination technologies, but designing membranes that achieve both high permeance and high salt rejection remains challenging. Here, the authors use sacrificial nanoparticles in the membrane fabrication process, leading to crumpled structures with ultrahigh permeance.
- Zhenyi Wang
- , Zhangxin Wang
- & Jian Jin
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Article
| Open AccessReprocessable thermosets for sustainable three-dimensional printing
Thermosetting polymers are widely used in 3D printing owing to their superior mechanical stability, but once they are printed, the highly crosslinked polmyers cannot be reprocessed or repaired. Here the authors demonstrate a two-step polymerization strategy toward 3D printing of reprocessable thermosets.
- Biao Zhang
- , Kavin Kowsari
- & Qi Ge
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Article
| Open AccessTransparent and attachable ionic communicators based on self-cleanable triboelectric nanogenerators
Flexible, transparent wearable electronics harvesting energy from human motion are nearing reality, but stable adhesion while staying clean remains a problem. Here the authors solve both issues with a functionalized organic polymer/hydrogel-based device capable of wireless communication via finger gestures.
- Younghoon Lee
- , Seung Hee Cha
- & Jeong-Yun Sun
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Article
| Open AccessFlutter to tumble transition of buoyant spheres triggered by rotational inertia changes
Spiral and zigzag trajectories of rising bubbles and falling leaves represent some of the path instabilities commonly observed for objects moving through fluids. Here, Mathai et al. show that the moment-of-inertia plays a crucial role in triggering such path instabilities for rising spherical particles.
- Varghese Mathai
- , Xiaojue Zhu
- & Detlef Lohse
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Article
| Open AccessReconfigurable engineered motile semiconductor microparticles
Active particles that demonstrate life-like behavior may find use in bio-inspired technologies, but achieving on-demand reconfiguration remains challenging. Here, the authors demonstrate controllable, collective behavior in silicon microparticles, which are fabricated via conventional semiconductor methods.
- Ugonna Ohiri
- , C. Wyatt Shields IV
- & Nan Jokerst
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Article
| Open AccessTopologically guided tuning of Zr-MOF pore structures for highly selective separation of C6 alkane isomers
The separation of C6 alkane isomers is crucial to the petroleum refining industry, but the distillation methods in place are energy intensive. Here, the authors design a series of topologically-guided zirconium-based metal-organic frameworks with optimized pore structures for efficient C6 alkane isomer separations.
- Hao Wang
- , Xinglong Dong
- & Jing Li
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Article
| Open AccessContrast-enhanced ultrasound measurement of pancreatic blood flow dynamics predicts type 1 diabetes progression in preclinical models
Non-invasive techniques to assess the progression of type 1 diabetes prior to clinical onset are needed. Here the authors apply a contrast-enhanced ultrasound measurement of mouse pancreatic blood flow to detect changes in the islet microvasculature that undergoes rearrangements during diabetes and predict disease progression.
- Joshua R. St Clair
- , David Ramirez
- & Richard K. P. Benninger
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Article
| Open AccessAerodynamic generation of electric fields in turbulence laden with charged inertial particles
How lightning occurs in dusty atmospheres remains largely unknown because of the complexity of the turbulent flows involved. Di Renzo and Urzay reveal a flow-driven mechanism of charge separation by simulating turbulence laden with hundreds of millions of electrically charged inertial particles.
- M. Di Renzo
- & J. Urzay
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Article
| Open AccessMolecular doping enabled scalable blading of efficient hole-transport-layer-free perovskite solar cells
The existing hole-transporting materials cause problems in the cost and scalability of the perovskite solar cells. Here Wu et al. fabricate high efficiency cells by molecularly doping the perovskite layer without using hole-transporting layers, thus simplify the device architecture and processing steps.
- Wu-Qiang Wu
- , Qi Wang
- & Jinsong Huang
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Article
| Open AccessGauging force by tapping tendons
Mechanical forces exerted on tendons during locomotion cannot be readily measured without invasive methods. Here, the authors develop a non-invasive wearable device to track tendon loads by measuring shear wave propagation speed, and demonstrate its use during dynamic human movements.
- Jack A. Martin
- , Scott C. E. Brandon
- & Darryl G. Thelen
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Article
| Open AccessHigh spectral resolution of gamma-rays at room temperature by perovskite CsPbBr3 single crystals
Detection and spectroscopic measurements of gamma-ray used to rely on expensive materials such as CdZnTe crystals. Here He et al. develop a melt method to grow large size CsPbBr3 perovskite crystals and the devices achieve low cost, high energy resolving capabilities and stability.
- Yihui He
- , Liviu Matei
- & Mercouri G. Kanatzidis
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Article
| Open AccessNeural-like computing with populations of superparamagnetic basis functions
Population coding, where populations of artificial neurons process information collectively can facilitate robust data processing, but require high circuit overheads. Here, the authors realize this approach with reduced circuit area and power consumption, by utilizing superparamagnetic tunnel junction based neurons.
- Alice Mizrahi
- , Tifenn Hirtzlin
- & Damien Querlioz
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Article
| Open AccessPharmaceutical concentration using organic solvent forward osmosis for solvent recovery
Solvent recovery is an important process in the pharmaceutical industry, but organic solvent nanofiltration membranes operate under high pressures. Here the authors demonstrate organic solvent forward osmosis — an alternative process that does not require application of external pressure and may prove to be economically favorable.
- Yue Cui
- & Tai-Shung Chung
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Article
| Open AccessEnergy-loss return gate via liquid dielectric polarization
One major energy loss in electronics is heat dissipation due to induced polarization in dielectric materials in the presence of electric fields. Kim et al. utilize large polarization in liquids to harvest dielectric loss via an energy-loss return gate design, which converts energy back to electricity.
- Taehun Kim
- , Hyungseok Yong
- & Sangmin Lee
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Article
| Open AccessUnderstanding the adsorption process in ZIF-8 using high pressure crystallography and computational modelling
Understanding host–guest interactions and structural changes within porous materials is crucial for enhancing gas storage properties. Here, the authors combine cryogenic loading of gases with high pressure crystallography and computational techniques to obtain atomistic detail of adsorption-induced structural and energetic changes in ZIF-8.
- Claire L. Hobday
- , Christopher H. Woodall
- & Stephen A. Moggach
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Article
| Open AccessHigh-sensitivity ion detection at low voltages with current-driven organic electrochemical transistors
The organic electrochemical transistor is a type of transistor that modulates the channel current by the ion concentration and is thus explored for bio-applications. Here Ghittorelli et al. show a current-driven device configuration to increase the sensitivity by ten times than conventional approaches.
- Matteo Ghittorelli
- , Leona Lingstedt
- & Fabrizio Torricelli
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Article
| Open AccessCombining CO2 reduction with propane oxidative dehydrogenation over bimetallic catalysts
The oxidative dehydrogenation of propane by CO2 (CO2-ODHP) can potentially fill the gap of propylene production while consuming a greenhouse gas. Here, the authors identify non-precious FeNi and precious NiPt catalysts supported on CeO2 as promising catalysts for CO2-ODHP and dry reforming, respectively, in flow reactor studies.
- Elaine Gomez
- , Shyam Kattel
- & Jingguang G. Chen
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Article
| Open AccessHorn-like space-coiling metamaterials toward simultaneous phase and amplitude modulation
Acoustic metasurfaces can be used to control acoustic waves, but generally they focus on phase control which limits potential functionality. Here, Ghaffarivardavagh et al. analytically develop a horn-like space coiling acoustic metasurface to control both the amplitude and phase of acoustic radiation patterns.
- Reza Ghaffarivardavagh
- , Jacob Nikolajczyk
- & Xin Zhang
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Article
| Open AccessObservation of elastic topological states in soft materials
Here the authors present an experimental observation of topological states in soft elastic metamaterials. They show reversibility in topological phases by changing filling ratio, tension and/or compression, while also demonstrating tunability of topological interface states by mechanical deformation.
- Shuaifeng Li
- , Degang Zhao
- & Jianfeng Zang
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Article
| Open AccessOn-chip temporal focusing of elastic waves in a phononic crystal waveguide
Here the authors demonstrate the temporal control of ultrasonic wave propagation in a one-dimensional phononic crystal waveguide. Four-wave mixing experiments are implemented, providing a platform on which to realize novel nonlinear phenomena in the system.
- M. Kurosu
- , D. Hatanaka
- & H. Yamaguchi
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Article
| Open AccessTowards an arthritis flare-responsive drug delivery system
The treatment of inflammatory arthritis by local delivery of therapeutics is limited by short half-lives of drugs. Here the authors demonstrate a hydrogel platform that titrates drug release to arthritis activity.
- Nitin Joshi
- , Jing Yan
- & Jeffrey M. Karp
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Article
| Open AccessA high-brightness large-diameter graphene coated point cathode field emission electron source
Traditional cold field emission electron sources rely on single crystal tungsten sharpened wires. Here, the authors use graphene-coated nickel point cathodes to devise alternative cold field emission electron sources for electron microscopy and lithography applications.
- Xiuyuan Shao
- , Avinash Srinivasan
- & Anjam Khursheed
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| Open AccessFluorescent label-free quantitative detection of nano-sized bioparticles using a pillar array
The detection and quantification of bioparticles is important to a range of applications including disease diagnostics. Here, the authors present a fluorescent label-free detection method using deterministic lateral displacement and demonstrate its use in detecting a range of proteins and vesicles.
- Kerwin Kwek Zeming
- , Thoriq Salafi
- & Yong Zhang
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| Open AccessLarge-area and bright pulsed electroluminescence in monolayer semiconductors
Atomically thin monolayers with high photoluminescence quantum yield are promising for optoelectronic and lighting applications. Here, the authors fabricate a transient-mode electroluminescent device to bypass the requirement of ohmic contacts for electrons and holes, and observe millimetre-scale light emission from a transparent 2D display.
- Der-Hsien Lien
- , Matin Amani
- & Ali Javey
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Article
| Open AccessSilicon and glass very large scale microfluidic droplet integration for terascale generation of polymer microparticles
Microfluidic-generated polymer microparticles have been shown to have superior pharmacological performance; yet, mass production remains a challenge to industrial application. Here, the authors present and test a device that incorporates arrays of microparticle generators for mass production.
- Sagar Yadavali
- , Heon-Ho Jeong
- & David Issadore
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Article
| Open AccessAdsorption-based atmospheric water harvesting device for arid climates
Harvesting water from the atmosphere is an important solution to water scarcity, but doing so in arid climates is highly challenging. Here, the authors develop a metal-organic framework-based water harvesting device that can deliver over 0.25 L of water per kg of adsorbent over a single cycle at relative humidities of 10–40% and at subzero dew points.
- Hyunho Kim
- , Sameer R. Rao
- & Evelyn N. Wang
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Article
| Open AccessSurface tension-assisted additive manufacturing
Integrating cell-laden hydrogels effectively into the 3D printing process is a challenge in the creation of tissue engineering scaffolds. Here, the authors describe an additive manufacturing technique to combine polymer and cell-containing networks with 3D-printed mechanical supports.
- Héloïse Ragelle
- , Mark W. Tibbitt
- & Robert Langer
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Article
| Open AccessArchimedes’ law explains penetration of solids into granular media
The penetration dynamics of solid objects into granular media has been described by theories that are constrained to the use of phenomenological models or empirical parameters. Here, Kang et al. propose and test a parameter-free model for the dependence of the resistance force on penetration depth.
- Wenting Kang
- , Yajie Feng
- & Raphael Blumenfeld
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Article
| Open AccessChemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer
Photothermal therapy (PTT) for cancer treatment is currently limited to local, accessible, tumors. Here the authors show that PTT combination with chemotherapy, by stimulating an immune response, is effective against distant tumors and establishes immune memory, thus providing a strategy to target metastatic disease.
- Jutaek Nam
- , Sejin Son
- & James J. Moon
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Article
| Open AccessDesign and validation of a foldable and photovoltaic wide-field epiretinal prosthesis
Retinal prostheses are being developed to fight severe retinal diseases where wider visual field and higher visual acuity are desired. Here Ferlauto et al. design a foldable and wide-field epiretinal prosthesis that can meet the performance and safety requirements and show a long lifetime of 2 years.
- Laura Ferlauto
- , Marta Jole Ildelfonsa Airaghi Leccardi
- & Diego Ghezzi
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Article
| Open AccessNanowire arrays restore vision in blind mice
The restoration of light response using retinal prosthesis could be a way to restore vision following retinal degenerative disease. Here the authors develop gold-titania nanowire arrays that restore visual response in blind mice.
- Jing Tang
- , Nan Qin
- & Gengfeng Zheng
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Article
| Open AccessDecomposing the Bragg glass and the peak effect in a Type-II superconductor
The disordering of the vortex lattice in a type-II superconductor is widely perceived to underpin unusual peaks in the temperature and field dependence of critical current. By contrast, here Toft-Petersen et al. find an order-disorder transition in a superconducting vanadium sample that is unconnected with peaks observed in critical current.
- Rasmus Toft-Petersen
- , Asger B. Abrahamsen
- & Mark Laver
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Article
| Open AccessFormation of size-dependent and conductive phase on lithium iron phosphate during carbon coating
Coating the active materials of interest with carbon is a widely employed way to boost the performance of lithium ion batteries. Here the authors show the formation of a conductive phase on LiFePO4 during carbon coating, which is size, annealing temperature and reduction atmosphere dependent.
- Yulong Liu
- , Jian Liu
- & Xueliang Sun
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Review Article
| Open AccessRecent progress and perspectives of space electric propulsion systems based on smart nanomaterials
Miniaturized spacecraft built from advanced nanomaterials are poised for unmanned space exploration. In this review, the authors examine the integration of nanotechnology in electric propulsion systems and propose the concept of self-healing and adaptive thrusters.
- I. Levchenko
- , S. Xu
- & M. Keidar
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Article
| Open Access3D printing of robotic soft actuators with programmable bioinspired architectures
3D-printed soft actuators have limited motion and are far from reaching the level of complexity found in biological systems. Here the authors present a multimaterial 3D printing platform for the fabrication of soft actuators displaying a wide range of motions that are programmable.
- Manuel Schaffner
- , Jakob A. Faber
- & André R. Studart