Research Highlight |
Featured
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Research Highlight |
Hormone therapy ameliorates ICI-related myocarditis in mice
Some clinical observations suggest that female patients are more susceptible to myocarditis induced by immune-checkpoint-inhibitor therapies. A new study recapitulates this female predisposition in mice and provides mechanistic and biological plausibility, and suggests that hormone therapy could help to treat myocarditis by promoting the expression of MANF, a protein related to the unfolded protein response.
- Irene Fernández-Ruiz
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Review Article |
Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
The cardiotoxicity spectrum of cancer therapies has broadened and is gaining increasing importance with an ever-growing repertoire of therapeutics. This Review provides an updated overview of cardiotoxicity and arrhythmias associated with cancer therapies, summarizing the latest developments at the juncture of cardiology, oncology and haematology and the emerging field of cardio-oncology.
- Joerg Herrmann
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Review Article |
Vascular toxic effects of cancer therapies
This Review outlines the mechanisms of cancer therapy-related vascular toxicity and provides recommendations for screening, treatment and prevention in the context of available evidence and society guidelines. The Review focuses on the main types of arterial toxicity, acute vasospasm, acute thrombosis and accelerated atherosclerosis, and provides an update on cancer therapy-related venous thromboembolism and pulmonary hypertension.
- Joerg Herrmann
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News & Views |
Can heart failure cause cancer?
Cardiovascular disease and cancer share several risk factors. Patients with heart failure have a higher rate of cancer than healthy control populations. Meijers and colleagues have taken this association a step further to present new evidence suggesting that, beyond simply sharing root causes, heart failure might actually cause cancer.
- A. Mark Richards
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News & Views |
Cardiovascular disease and breast cancer
Advances in breast cancer therapy mean that more women are surviving cancer but are at increased risk of cardiovascular disease (CVD). In a statement released by the AHA, Mehta and colleagues summarize the intersection between breast cancer and CVD, and highlight the importance of vigilance in preventive measures.
- Melissa Moey
- & Javid Moslehi
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Research Highlight |
Targeting inflammatory pathways to treat atherosclerosis and cancer
- Karina Huynh
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Review Article |
Pathology, imaging, and treatment of cardiac tumours
Cardiac tumours include a wide array of both neoplastic and non-neoplastic entities. Cardiac tumours are often found incidentally during imaging by ultrasonography, CT, or MRI. In this Review, Maleszewiski and colleagues discuss the clinical presentation, imaging characteristics, pathological characteristics, and treatment of these lesions.
- Joseph J. Maleszewski
- , Nandan S. Anavekar
- & Kyle W. Klarich
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Research Highlight |
New meta-analysis shows no cancer risk with angiotensin-receptor blockers
- Bryony M. Mearns
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Review Article |
Cardiotoxicity of anticancer treatments: what the cardiologist needs to know
Cancer therapies can have a profound, and often permanent, effect on the cardiovascular system. Patients at high risk of cardiotoxicity should be identified before treatment, closely monitored, and given cardioprotective agents to reduce adverse events. The authors of this Review discuss the complications that can occur as a result of cancer therapy, and emphasize the importance of assessing both the cardiotoxicity and benefits of cancer treatment.
- Michael S. Ewer
- & Steven M. Ewer
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