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p66Shc and Ras: controlling anoikis from the inside-out

Oncogene volume 29, pages 5556–5558 (2010)Cite this article

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Abstract

Protection from detachment-induced cell death, termed anoikis, facilitates metastasis. Though anoikis is largely attributed to the loss of integrin-related ‘outside-in’ survival signals, Terada and colleagues demonstrate a novel ‘inside-out’ attachment sensing role for the adapter protein p66Shc in promoting anoikis and suppressing metastasis via Ras-dependent control of proliferation and survival.

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Acknowledgements

JD is supported by Grants from the NIH (RO1CA126792; CA126792-S1 ARRA) and the California Tobacco Related Disease Research Program (18XT-0106).

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  1. Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA

    J Debnath

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  1. J Debnath
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Correspondence to J Debnath.

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Debnath, J. p66Shc and Ras: controlling anoikis from the inside-out. Oncogene 29, 5556–5558 (2010). https://doi.org/10.1038/onc.2010.347

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