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Volume 15 Issue 4, April 2008

The INO80 chromatin-remodeling complex has roles in transcription, DNA repair and replication. Papamichos-Chronakis and Peterson now show that Ino80 regulates efficient fork progression, stabilizes stalled forks and helps ensure proper restart. The cover photograph, from Creatas Images, represents the replication fork.pp 338-345, News and Views p 332

Volume 15 Issue 4

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Editorial

  • On 12 March 2008, the US Environmental Protection Agency (EPA) released its latest standards for ozone emission, along with recommendations on how to update the Clean Air Act. This was followed by public outcry from medical associations, nonprofit organizations and media outlets.

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News & Views

  • The INO80 chromatin-remodeling complex has roles in transcription, DNA repair and replication. By studying the role of Ino80 in DNA replication, a study now finds that the INO80 complex is essential for replication fork progression under conditions of replicative stress, stabilizes stalled forks and helps ensure proper restart.

    • Kelly M Trujillo
    • Mary Ann Osley
    News & Views

  • Two proposed mechanisms for how microRNAs (miRNAs) and their associated Argonaute proteins inhibit translation in mammals do not seem to operate in Drosophila melanogaster cells, suggesting that insights into important miRNA functions remain elusive. However, the interaction between Argonaute and the P-body factor GW182 may help in elucidating the biochemical basis of translational control by miRNAs.

    • Joel D Richter
    News & Views

    • Sabbi Lall
    News & Views
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