Recent studies have highlighted a potentially important role for Wnts as profibrotic mediators, and implicated increased Wnt activity in systemic sclerosis and other fibrotic diseases. Strikingly, new data indicates that Wnts have a central role in the profibrotic activity of TGF-β.
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Lafyatis, R. SSc—fibrosis takes flight with Wingless inhibition. Nat Rev Rheumatol 8, 441–442 (2012). https://doi.org/10.1038/nrrheum.2012.99
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DOI: https://doi.org/10.1038/nrrheum.2012.99
