In an age in which immunosuppression is the standard of care for many pediatric rheumatic diseases, balancing the risks and benefits of vaccinations is forefront. Three main issues—addressed in new guidelines—surround vaccination practices in these patients: safety, immunogenicity and effects of the vaccine on the underlying rheumatic disease.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Tynjala, P. et al. Aggressive combination drug therapy in very early polyarticular juvenile idiopathic arthritis (ACUTE-JIA): a multicentre randomised open-label clinical trial. Ann. Rheum. Dis. 70, 1605–1612 (2011).
Ilowite, N. T. et al. Impaired in vivo and in vitro antibody responses to bacteriophage phi X 174 in juvenile rheumatoid arthritis. J. Rheumatol. 14, 957–963 (1987).
Heijstek, M. W. et al. EULAR recommendations for vaccination in paediatric patients with rheumatic diseases. Ann. Rheum. Dis. 70, 1704–1712 (2011).
Aikawa, N. E. et al. Corticosteroid: major factor for reduced immunogenicity of 2009 influenza A (H1N1) vaccine in patients with juvenile autoimmune rheumatic disease. J. Rheumatol. 39, 167–173 (2012).
Dell'era, L. et al. Immunogenicity, safety and tolerability of MF59-adjuvanted seasonal influenza vaccine in children with juvenile idiopathic arthritis. Vaccine 30, 936–940 (2012).
Long, C. B. et al. Humoral and cell-mediated immune responses to monovalent 2009 influenza A/H1N1 and seasonal trivalent influenza vaccines in high-risk children. J. Pediatr. 160, 74–81 (2012).
Rehnberg, M. et al. Vaccination response to protein and carbohydrate antigens in patients with rheumatoid arthritis after rituximab treatment. Arthritis Res. Ther. 12, R111 (2010).
Perricone, C., Agmon-Levin, N., Valesini, G. & Shoenfeld, Y. Vaccination in patients with chronic or autoimmune rheumatic diseases: the ego, the id and the superego. Joint Bone Spine 79, 1–3 (2012).
Shoenfeld, Y. & Agmon-Levin, N. 'ASIA' - autoimmune/inflammatory syndrome induced by adjuvants. J. Autoimmun. 36, 4–8 (2011).
Balofsky, A., Agmon-Levin, N. & Shoenfeld, Y. The new H1N1 and HPV vaccines and old fears. Curr. Opin. Rheumatol. 22, 431–436 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
N. T. Ilowite has acted as a consultant for Genentech and Novartis, and has received grant or research support from Regeneron. G. Janow declares no competing interests.
Rights and permissions
About this article
Cite this article
Janow, G., Ilowite, N. Vaccination in pediatric rheumatic disease—risks and benefits. Nat Rev Rheumatol 8, 188–190 (2012). https://doi.org/10.1038/nrrheum.2012.13
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrrheum.2012.13
This article is cited by
-
Vaccinations in juvenile chronic inflammatory diseases: an update
Nature Reviews Rheumatology (2013)