Genotyping analysis of a Turkish cohort of 1,900 patients with Behçet disease and 1,779 controls, in addition to two replication cohorts, adds ADO–EGR2, RIPK2, LACC1, and IRF8 to the list of known suspectibility loci shared by Behçet disease and Crohn's disease. A number of immune-related loci, such as IL1A–IL1B and FUT2, were also associated with Behçet disease, implicating the host response to microbial exposure in susceptibility to Behçet disease.
References
Takeuchi, M. et al. Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet's disease susceptibility. Nat. Genet. http://dx.doi.org/10.1038/ng.3786 (2017)
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McHugh, J. Shared genetic risk for Behçet disease and Crohn's disease. Nat Rev Rheumatol 13, 197 (2017). https://doi.org/10.1038/nrrheum.2017.30
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DOI: https://doi.org/10.1038/nrrheum.2017.30
