Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Connective tissue diseases

New criteria improve recognition of early systemic sclerosis

In systemic sclerosis (SSc), new classification criteria highly sensitive to early and limited forms of the disease could facilitate not only the recognition of early SSc, but also the discovery of biomarkers of poor prognosis, with potential benefits for conducting clinical trials.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Alhajeri, H. et al. The 2013 ACR/EULAR classification criteria for systemic sclerosis out-perform the 1980 criteria. Data from the Canadian Scleroderma Research Group. Arthritis Care Res. (Hoboken) http://dx.doi.org/10.1002/acr.22451.

  2. [No authors listed] Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Arthritis Rheum. 23, 581–590 (1980).

  3. Nadashkevich, O., Davis, P. & Fritzler, M. J. A proposal of criteria for the classification of systemic sclerosis. Med. Sci. Monit. 10, CR615–CR621 (2004).

    PubMed  Google Scholar 

  4. Lonzetti, L. S. et al. Updating the American College of Rheumatology preliminary classification criteria for systemic sclerosis: addition of severe nailfold capillaroscopy abnormalities markedly increases the sensitivity for limited scleroderma. Arthritis Rheum. 44, 735–736 (2001).

    Article  CAS  Google Scholar 

  5. van den Hoogen, F. et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 65, 2737–2747 (2013).

    Article  Google Scholar 

  6. van den Hoogen, F. et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann. Rheum. Dis. 72, 1747–1755 (2013).

    Article  Google Scholar 

  7. White, B. et al. Guidelines for clinical trials in systemic sclerosis (scleroderma). I. Disease-modifying interventions. The American College of Rheumatology Committee on Design and Outcomes in Clinical Trials in Systemic Sclerosis. Arthritis Rheum. 38, 351–360 (1995).

    Article  CAS  Google Scholar 

  8. Amjadi, S. et al. Course of the modified Rodnan skin thickness score in systemic sclerosis clinical trials: analysis of three large multicenter, double-blind, randomized controlled trials. Arthritis Rheum. 60, 2490–2498 (2009).

    Article  Google Scholar 

  9. LeRoy, E. C. & Medsger, T. A. Criteria for the classification of early systemic sclerosis. J. Rheumatol. 28, 1573–1576 (2001).

    CAS  PubMed  Google Scholar 

  10. Minier, T. et al. Preliminary analysis of the Very Early Diagnosis of Systemic Sclerosis (VEDOSS) EUSTAR multicentre study: evidence for puffy fingers as a pivotal sign for suspicion of systemic sclerosis. Ann.Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2013-203716.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shinichi Sato.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Asano, Y., Sato, S. New criteria improve recognition of early systemic sclerosis. Nat Rev Rheumatol 11, 3–4 (2015). https://doi.org/10.1038/nrrheum.2014.191

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrrheum.2014.191

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing