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Insight into the immunopathogenesis of crystal-induced inflammation has opened the door to a new approach to therapy. Could interleukin-1 antagonists be the answer to managing acute gout?
Transcriptomics and proteomics are transforming our understanding of juvenile idiopathic arthritis by revealing molecular signatures associated with the various clinical classifications. The challenge now is to find biomarkers that will predict disease course and response to medication in order to improve outcomes for children with arthritis.
Golimumab effectively reduces the signs and symptoms of active rheumatoid arthritis in patients who have previously failed treatment with at least one tumor necrosis factor inhibitor. Is it now time to develop strategies for sequential drug administration?
Randomized controlled trials investigating non-pharmacological therapies for hand osteoarthritis are rare. One such study now suggests that neoprene splints could be effective for the treatment of base-of-thumb osteoarthritis—but some questions remain unanswered.
In this Case Study, the authors describe a patient with Poncet disease, a rare form of polyarthritis associated with tuberculosis infection. They discuss their application of interferon-γ-release assays and PCR specific for DNA of theMycobacteria tuberculosis complex to make the diagnosis, despite a negative M. tuberculosisculture.
Vaccines are vital for protecting us against infectious diseases, but they have also been linked with the development of autoimmunity. In this article, the authors discuss the causal and temporal interactions between vaccines and autoimmune phenomena, and possible mechanisms by which different components of vaccines might induce autoimmune disease.
Monitoring disease activity and physical function is a fundamental aspect of spondyloarthritis management. Advances and recommendations in the field of spondyloarthritis monitoring, both in routine care and in the presence of a specific indication, are discussed in this Review.
Epidemiologic, genetic and immunophenotypic evidence suggests that oligoarticular and polyarticular subtypes of juvenile idiopathic arthritis are distinct etiopathologic conditions with some overlapping pathogenic pathways. As discussed in this Review, further research is needed before we can generate a full molecular picture of these chronic childhood arthropathies.
Psoriatic arthritis follows a chronic, progressive course in most patients and joint damage can occur early in the disease. This article discusses advances in early diagnosis of this inflammatory musculoskeletal disorder, the various therapies that are available, as well as general guiding principles for treatment.