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This Case Study discusses the diagnostic and management challenges associated with the rare conversion of discoid lupus to antiphospholipid syndrome and systemic lupus erythematosus in a male patient in his 60s. This conversion resulted in dual pathology that primarily affected the patient's cerebral and renal vasculature.
This Case Study describes a rehabilitation program for an athletic man who sustained an injury that caused knee joint effusion. The torque and muscle size of the injured leg was comparable to that of the patient's contralateral, healthy, leg after 11 weeks of a regimen incorporating repetition of knee aspiration and resistance training.
Pulmonary arterial hypertension (PAH) contributes significantly to the morbidity and mortality of patients with systemic sclerosis. Clinical symptoms of PAH are unspecific and are late manifestations of disease. This Case Study highlights the challenges of diagnosing PAH in patients with systemic sclerosis and includes discussion of screening options.
Erdheim–Chester disease is a rare form of non-Langerhans cell histiocytosis characterized by foamy histiocyte infiltration of the skeleton and viscera. A case of Erdheim–Chester disease that was initially mistaken for Ormond's disease is presented with a discussion of the tests required to differentiate between the two diagnoses.
Chronic recurrent multifocal osteomyelitis is the most severe form of chronic non-bacterial osteomyelitis and presents with clinical variability. This Case Study highlights the need for a multi-disciplinary approach for diagnosis and therapy of patients.
This Case Study describes a patient with human T lymphotropic virus type I-associated adult T cell leukemia/lymphoma complicated by arthritis. Although the patient died as a result of the adult T cell leukemia/lymphoma, the associated synovial swelling had markedly improved with alemtuzumab treatment.