A recent study has examined potential predictive markers of Alzheimer disease (AD) and stroke. The results challenge some current assumptions, suggesting that stroke might often follow a decade of deterioration in brain structure and function, and that cognitive and MRI markers of AD differ in older and younger individuals.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Comorbidity profile in dementia with Lewy bodies versus Alzheimer’s disease: a linkage study between the Swedish Dementia Registry and the Swedish National Patient Registry
Alzheimer's Research & Therapy Open Access 06 October 2014
Access options
References
Ballard, C. et al. Alzheimer's disease. Lancet 377, 1019–1031 (2011).
World Health Organization. Neurological Disorders: Public Health Challenges Ch. 2 (World Health Organization Press, 2006).
Weinstein, G. et al. Brain imaging and cognitive predictors of stroke and Alzheimer disease in the Framingham Heart Study. Stroke 44, 2787–2794 (2013).
Debette, S. et al. Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study. Stroke 41, 600–606 (2010).
Wiberg, B. et al. Cognitive function and risk of stroke in elderly men. Neurology 74, 379–385 (2010).
Jack, C. R. Jr et al. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol. 12, 207–216 (2013).
Johns, E. K. et al. The profile of executive functioning in amnestic mild cognitive impairment: disproportionate deficits in inhibitory control. J. Int. Neuropsychol. Soc. 18, 541–555 (2012).
O'Sullivan, M., Morris, R. G. & Markus, H. S. Brief cognitive assessment for patients with cerebral small vessel disease. J. Neurol. Neurosurg. Psychiatry 76, 1140–1145 (2005).
Acknowledgements
The authors thank the Biomedical Research Unit for Dementia at King's College London for supporting the writing of this article.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Ballard, C., O'Sullivan, M. Cognitive and neuroimaging predictors of AD and stroke. Nat Rev Neurol 9, 605–606 (2013). https://doi.org/10.1038/nrneurol.2013.215
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneurol.2013.215
This article is cited by
-
New insight of exercise on dementia; combinatory effects of physical and cognitive exercise
Molecular & Cellular Toxicology (2024)
-
Neohesperidin Prevents Aβ25–35-Induced Apoptosis in Primary Cultured Hippocampal Neurons by Blocking the S-Nitrosylation of Protein-Disulphide Isomerase
Neurochemical Research (2018)
-
Serum Aβ is Predictive for Short-Term Neurological Deficits After Acute Ischemic Stroke
Neurotoxicity Research (2015)
-
Comorbidity profile in dementia with Lewy bodies versus Alzheimer’s disease: a linkage study between the Swedish Dementia Registry and the Swedish National Patient Registry
Alzheimer's Research & Therapy (2014)