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Pediatric multiple sclerosis

E. Ann Yeh, Tanuja Chitnis, Lauren Krupp, Jayne Ness, Dorothée Chabas, Nancy Kuntz & Emmanuelle Waubant for the US Network of Pediatric MS Centers of Excellence

Despite its relative rarity, pediatric multiple sclerosis (MS) is an important entity, as it provides unique insights into disease processes related to MS. Clinical, MRI and laboratory data suggest differences in the immune response and CNS environment between adults and children with MS. Yeh et al. provide a comprehensive overview of the pediatric MS field, including epidemiology, disease mechanisms, diagnosis and treatment.

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Epilepsy: Generic substitution—are antiepileptic drugs different?

Carl W. Bazil

Generic drug substitution can markedly decrease the cost of health care. For conditions where agents have a relatively narrow therapeutic index, notably epilepsy, financial savings through generic substitution might be offset by increases in patient complications and related costs. Results from a study with topiramate support this view, particularly when a patient receives a drug from multiple manufacturers.

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Also in this issue

Research Highlights: Alzheimer disease: New susceptibility genes uncovered for AD

Research Highlights: Parkinson disease: Mixed results for rasagiline in PD

Research Highlights: Multiple sclerosis: Predicting the response to IFN- treatment in patients with MS

Current Issue

Also in this issue

Antiangiogenic therapies for high-grade glioma

Andrew D. Norden, Jan Drappatz & Patrick Y. Wen

High-grade gliomas are highly vascularized tumors that represent attractive targets for antiangiogenic therapies. In this article, Norden et al. discuss the rationale for targeting angiogenesis in high-grade gliomas and review the published clinical trial evidence, focusing primarily on therapies that target vascular endothelial growth factor and its receptors.