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Hypertension

Quarter dose quadpill combinations: a new therapeutic approach

Nature Reviews Nephrology volume 13, pages 266–267 (2017)Cite this article

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Achieving optimal blood pressure with antihypertensive agents in hypertensive patients can be particularly challenging. A major factor in this challenge is poor implementation of and compliance with multidrug regimens. However, a recent study shows encouraging results with a new single pill product that contains ultra-low doses of four antihypertensive agents.

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Figure 1: Comparison between low dose quadpill combination and multiple anti-hypertensive drugs.

References

  1. Mancia, G. et al. Blood pressure control in hypertension. Pros and cons of available treatment strategies. J. Hypertens. 35, 225–233 (2017).

    Article  CAS  PubMed  Google Scholar 

  2. Chow, G. et al. Quarter-dose quadruple combination therapy for initial treatment of hypertension: placebo-controlled, crossover, randomised trial and systematic review. Lancet 389, 1035–1042 (2017).

    Article  CAS  PubMed  Google Scholar 

  3. Mancia, G. et al. 2013 ESH/ESC guidelines for the management of arterial hypertension. The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC). J. Hypertens. 31, 1281–1357 (2013).

    Article  CAS  PubMed  Google Scholar 

  4. Mancia, G. & Verdecchia, P. Clinical value of ambulatory blood pressure: evidence and limits. Circ. Res. 116, 1034–1045 (2015).

    Article  CAS  PubMed  Google Scholar 

  5. The SPRINT Research Group. A randomized trial of intensive versus standard blood pressure control. N. Engl. J. Med. 373, 2103–2116 (2015).

  6. Ettehad, D. et al. Blood pressure lowering for prevention of cardiovascular disease and death. A systematic review and meta-analysis. Lancet 387, 957–961 (2016).

    Article  PubMed  Google Scholar 

  7. Mancia, G. & Parati, G. Office compared with ambulatory blood pressure in assessing response to antihypertensive treatment: a metaanalysis. J. Hypertens. 22, 435–445 (2004).

    Article  CAS  PubMed  Google Scholar 

  8. Mancia, G. & Grassi, G. Systolic and diastolic blood pressure control in antihypertensive drug trials. J. Hypertens. 20, 1461–1464 (2002).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Clinica Medica, University of Milano-Bicocca, Via Pergolesi 33, 20900 Monza, Italy; and at IRCCS Multimedica, Sesto San Giovanni, Via Milanese, 20099 Sesto San Giovanni, Milan, Italy.,

    Guido Grassi

  2. and at IRCCS Multimedica, Sesto San Giovanni, Via Milanese, 20099 Sesto San Giovanni, Milan, Italy.,

    Guido Grassi

  3. University of Milano-Bicocca, Piazza dell'Ateneo Nuovo, 1, Milan, 20126, Italy

    Giuseppe Mancia

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  1. Guido Grassi
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  2. Giuseppe Mancia
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Correspondence to Guido Grassi.

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The authors declare no competing financial interests.

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Grassi, G., Mancia, G. Quarter dose quadpill combinations: a new therapeutic approach. Nat Rev Nephrol 13, 266–267 (2017). https://doi.org/10.1038/nrneph.2017.45

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