Several recent studies have provided insights into the genetic regulation of blood pressure. A new study extends these findings by coupling genome-wide association study data with functional validation approaches to identify and explore loci associated with blood pressure, and by generating a genetic risk score model to predict future cardiovascular risk.
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Natural selection and local adaptation of blood pressure regulation and their perspectives on precision medicine in hypertension
Hereditas Open Access 07 January 2019
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Acknowledgements
D.L.M.'s research is supported by NIH Grants DK96859 and HL116264 and AHA 15SFRN2391002. M.L.'s research is supported by NIH Grants HL116264, HL121233, HL125409, GM066730, HL082798 and AHA 15SFRN2391002.
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Mattson, D., Liang, M. From GWAS to functional genomics-based precision medicine. Nat Rev Nephrol 13, 195–196 (2017). https://doi.org/10.1038/nrneph.2017.21
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DOI: https://doi.org/10.1038/nrneph.2017.21
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