Abstract
The best available data indicate that the world is heading towards a pandemic of extensively drug-resistant Neisseria gonorrhoeae. At the same time, clinical microbiology laboratories have moved away from using culture-based methods to diagnose gonorrhoea, thus undermining our ability to detect antimicrobial resistance (AMR) using current technologies. In this Opinion article, we discuss the problem of N. gonorrhoeae AMR, particularly emerging resistance to the cephalosporin ceftriaxone, outline current concerns about the surveillance of N. gonorrhoeae AMR and propose the use of molecular methods on a large scale to systematically enhance surveillance.
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Acknowledgements
This article results from the Gonorrhoea Resistance Assessment by Nucleic acid Detection (GRAND) study supported by an Australian National Health and Medical Research Council (NHMRC) Project Grant (APP1025517).
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Goire, N., Lahra, M., Chen, M. et al. Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance. Nat Rev Microbiol 12, 223–229 (2014). https://doi.org/10.1038/nrmicro3217
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DOI: https://doi.org/10.1038/nrmicro3217
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