Nature Reviews Immunology
Volume 9, No 11 November 2009
Featured Article
Regulation of tissue homeostasis by NF–κB signalling: implications for inflammatory diseases
Manolis Pasparakis
Article series: Tissue–specific immune responses
Main pages for finding content:
CURRENT ISSUE
Review
The follicular versus marginal zone B lymphocyte cell fate decision
Shiv Pillai & Annaiah Cariappa
This Review proposes an integrated model for the development of follicular versus marginal zone B cells based on the coordination of B cell receptor signal strength with signals through Notch2 and the receptor for B cell–activating factor and signals that are involved in the migration to and retention of B cells in the marginal zone of the spleen.
CURRENT ISSUE
Review
New insights into the differentiation and function of T follicular helper cells
Cecile King
T follicular helper cells are strategically positioned in germinal centres and equipped to provide the signals necessary for antibody production by B cells. This Review describes the latest studies that explore their development and function and their relationship with other T helper cell subsets.
CURRENT ISSUE
Review
Analysing immune cell migration
Joost B. Beltman, Athanasius F. M. Marée & Rob J. de Boer
Time–lapse video microscopy is an important experimental tool for examining the dynamic behaviour of immune cells in situ and involves quantitative analysis of cell migration and cell–cell interactions. Here, several commonly measured parameters and imaging artefacts are described and potential solutions to detect and correct these artefacts are proposed.
CURRENT ISSUE
Review
Intestinal mucosal barrier function in health and disease
Jerrold R. Turner
Mucosal surfaces are lined by epithelial cells that establish a barrier between external environments and the internal milieu. Recent advances have uncovered mechanisms of barrier regulation by immune stimuli and, conversely, how mucosal immunity is regulated by barrier function.
CURRENT ISSUE
Perspective
The functional plasticity of T cell subsets
Jeffrey A. Bluestone, Charles R. Mackay, John J. O'Shea & Brigitta Stockinger
The recent re–evaluation of the concept that CD4+ T helper cell subsets are irreversibly differentiated lineages has become one of the most hotly debated issues in immunology. Here, four leaders in the field provide their thoughts on the complexities and controversies surrounding the functional plasticity of T cell subsets.
MEETINGS
Immunology Conferences
Thinking about which meetings to attend in 2010? Visit our conference calendar for a list of forthcoming meetings and workshops relevant to immunologists. If you are organising a meeting that you would like to be included in this list, please email the details to nri@nature.com for consideration.
More Immunology
-
Signaling Gateway
The free one-stop resource for all cell-signalling researchers
-
Immunology@nature.com
More articles on immunology, from the Nature Publishing Group
-
Cell Migration Gateway
The definitive online resource for all the latest developments in cell migration
-
Immunology Conferences
A calendar of forthcoming meetings and workshops from across the field of immunology.
-
Nature Reports Avian Flu
The latest research news, comments and analysis on avian flu
-
Recommended Links
Links recommended by the editors
Noticeboard
Focus on neuroimmunology
Understanding the crosstalk between the nervous and immune systems and how it can be dysregulated provides us with crucial insights necessary for the treatment of neurological diseases such as multiple sclerosis and Alzheimer's disease. Nature Reviews Immunology presents a special Focus issue featuring articles that review our current understanding of the immunopathogenesis of and emergent immunotherapies for these neurological diseases.
Poster on Type I interferon and SLE
The study of Systemic Lupus Erythematosus (SLE) patients has revealed a central role for IFN–α in disease pathogenesis. This poster provides an overview of how IFN signaling is intimately involved in SLE pathogenesis. The poster is available thanks to support from PBL InterferonSource.
Poster on Antigen processing and presentation
This poster provides an updated overview of the intracellular pathways and mechanisms by which antigens are captured, processed and loaded onto MHC class I, class II and CD1d molecules for presentation to T cells. The poster is freely available thanks to support from StemCell Technologies.
Focus on Immune Signaling Cross–talk
Nature Immunology presents a focus on the complex interplay among signaling pathways operative in immune cells. The focus contains a specially commissioned overview, three review articles and two perspectives. Also included are highlights of recent research findings and several short comments–written by experts—providing in–depth insight into specific signal cross–talk points.
Focus on CD4+ T–cell diversity
CD4+ T cells have a crucial role in orchestrating immune responses, as well as in immune regulation. The recent identification of IL–17–expressing T cells (TH17 cells) has raised fundamental questions about lineage commitment and fate determination of CD4+ T cells. This Focus describes the molecular pathways that govern the differentiation of TH1, TH2, TH17 and regulatory T cells.
Article series on Tissue–specific immune responses
In October 2008, Nature Reviews Immunology begin a series of articles related to tissue–specific immune responses. These articles will consider aspects of immune responses in the context of the tissue in which they occur and highlight how tissue cells or tissue–derived factors in different organs can shape the outcome of these responses.
Structural Genomics Knowledgebase
A new window onto the world of protein structure has opened with the new, free PSI–Nature Structural Genomics Knowledgebase (PSI–SGKB). The site makes available the research data and tools from the Protein Structure Initiative, complemented with structural biology updates from NPG. Users can also suggest proteins for structure analysis.
Focus on Dendritic Cells
This Focus from Immunology & Cell Biology presents a collection of review and research articles that outline our current understanding of DC heterogeneity, how different populations contribute to T–cell responses, and how T cells differentiate and maintain functional diversity.
Focus on Leukocyte Trafficking
This Focus from Nature Immunology presents five specially commissioned reviews and an overview that discuss how immune cells traffic through tissues and lymphoid organs.
Nature Reviews Genetics Wiki
Nature Reviews Genetics presents a first for Nature Publishing Group — a Review that can be commented on, updated, and added to by readers using Wiki features. The Review explores the past, present and future of the biology cyberinfrastructure.
Focus on Mucosal Immunology
This Focus from Nature Reviews Immunology highlights the latest advances in our understanding of host–microbe interactions at mucosal sites and the consequences of immune dysregulation at these sites.
Focus on Natural Killer Cells
Nature Immunology presents a series of specially commissioned articles that focus on the differentiation, responsiveness and biological roles of natural killer cells. The focus is available free to registrants for 6 months.
Focus on Allergy and Asthma
Millions of people worldwide suffer from respiratory diseases such as allergies, asthma and chronic obstructive pulmonary disease, and these diseases constitute a major public health burden. This Focus issue highlights the latest advances in our understanding of the immune bases of these diseases and outlines how this knowledge can be translated into more effective treatment strategies.
Poster on innate immunity: sensing and signalling
This poster provides an overview of the components and networks involved in pathogen sensing and signalling in the innate immune system. The poster is freely available thanks to support from MedImmune.
Web Focuses
Please visit our Web Focuses, which provide a selection of articles on a related theme drawn from Nature Publishing Group on key current topics of immunology.
Posters
Our Posters provide a visual overview of a hot topic in immunology. Thanks to generous support, they are freely available and can be viewed online as a high–resolution PDF.
2008 Journal Citation Report (Thomson Reuters, 2009)
