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Neurogastroenterology in 2011

Emerging concepts in neurogastroenterology and motility

Neurogastroenterology encompasses intrinsic and extrinsic neural processes that regulate gut functions, sensation and related behaviors such as ingestion. In 2011, key advances were made in understanding gut–brain interactions, visceral sensation, serotonin signaling, neurogenesis and neuromuscular transmission.

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References

  1. Van Oudenhove, L. et al. Fatty acid-induced gut-brain signaling attenuates neural and behavioral effects of sad emotion in humans. J. Clin. Invest. 121, 3094–3099 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Bravo, J. A. et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc. Natl Acad. Sci. USA 108, 16050–16055 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Ibeakanma, C. et al. Brain-gut interactions increase peripheral nociceptive signaling in mice with postinfectious irritable bowel syndrome. Gastroenterology 141, 2098–2108 (2011).

    Article  CAS  PubMed  Google Scholar 

  4. Bradesi, S. et al. Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 301, G580–G589 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Laranjeira, C. et al. Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury. J. Clin. Invest. 121, 3412–3424 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Joseph, N. M. et al. Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut. J. Clin. Invest. 121, 3398–3411 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Cremon, C. et al. Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome. Am. J. Gastroenterol. 106, 1290–1298 (2011).

    Article  CAS  PubMed  Google Scholar 

  8. Li, Z. et al. Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. J. Neurosci. 31, 8998–9009 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Tsuchida, Y. et al. Neuronal stimulation with 5hydroxytryptamine 4 receptor induces anti-inflammatory actions via α7nACh receptors on muscularis macrophages associated with postoperative ileus. Gut 60, 638–647 (2011).

    Article  CAS  PubMed  Google Scholar 

  10. Kurahashi, M. et al. A functional role for the 'fibroblast-like cells' in gastrointestinal smooth muscles. J. Physiol. 589, 697–710 (2011).

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Keith A. Sharkey.

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Sharkey, K., Mawe, G. Emerging concepts in neurogastroenterology and motility. Nat Rev Gastroenterol Hepatol 9, 74–76 (2012). https://doi.org/10.1038/nrgastro.2011.247

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