Review

Nature Reviews Genetics 11, 97-108 (February 2010) | doi:10.1038/nrg2689

The evolution of gene duplications: classifying and distinguishing between models

Hideki Innan1,2 & Fyodor Kondrashov3  About the authors

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Gene duplications and their subsequent divergence play an important part in the evolution of novel gene functions. Several models for the emergence, maintenance and evolution of gene copies have been proposed. However, a clear consensus on how gene duplications are fixed and maintained in genomes is lacking. Here, we present a comprehensive classification of the models that are relevant to all stages of the evolution of gene duplications. Each model predicts a unique combination of evolutionary dynamics and functional properties. Setting out these predictions is an important step towards identifying the main mechanisms that are involved in the evolution of gene duplications.

Author affiliations

  1. Graduate University for Advanced Studies, Hayama, Kanagawa 240-0193, Japan.
    Email: innan_hideki@soken.ac.jp
  2. PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan.
  3. Bioinformatics and Genomics Programme, Centre for Genomic Regulation, C/Dr Aiguader 88, Barcelona Biomedical Research Park Building, 08003 Barcelona, Spain.
    Email: fyodor.kondrashov@crg.es

Published online 6 January 2010

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