A recent report has identified uroguanylin as an endocrine signal that exerts a physiological role in energy homeostasis, adding another factor to the gut–brain axis. From a clinical point of view, several observations highlight the uroguanylin–guanylyl cyclase C pathway as a potential therapeutic target for the development of antiobesity drugs.
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References
Potter, L. R. Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases. Pharmacol. Ther. 130, 71–82 (2011).
Valentino, M. A. et al. A uroguanylin–GUCY2C endocrine axis regulates feeding in mice. J. Clin. Invest. 121, 3578–3588 (2011).
Lorenz, J. N. et al. Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load. J. Clin. Invest. 112, 1244–1254 (2003).
Lin, J. E. et al. The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling. Gastroenterology 138, 241–254 (2010).
Steinbrecher, K. A. et al. Murine guanylate cyclase C regulates colonic injury and inflammation. J. Immunol. 186, 7205–7214 (2011).
Flemström, G., Bengtsson, M. W., Mäkelä, K. & Herzig, K. H. Effects of short-term food deprivation on orexin-A-induced intestinal bicarbonate secretion in comparison with related secretagogues. Acta Physiol. (Oxf.) 198, 373–380 (2010).
Kokrashvili, Z. et al. Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5. Gastroenterology 137, 598–606 (2009).
Liedtke, W. B. et al. Relation of addiction genes to hypothalamic gene changes subserving genesis and gratification of a classic instinct, sodium appetite. Proc. Natl Acad. Sci. USA 108, 12509–12514 (2011).
Gong, R. et al. Role for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior. Science 333, 1642–1646 (2011).
Munger, S. D. et al. An olfactory subsystem that detects carbon disulfide and mediates food-related social learning. Curr. Biol. 20, 1438–1444 (2010).
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Frühbeck, G. Uroguanylin—a new gut-derived weapon against obesity?. Nat Rev Endocrinol 8, 5–6 (2012). https://doi.org/10.1038/nrendo.2011.206
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DOI: https://doi.org/10.1038/nrendo.2011.206
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