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Update on bone-modifying agents in metastatic breast cancer

A Correction to this article was published on 22 August 2011

This article has been updated

Advances in the development of bone-modifying agents have led to the approval of new drugs for the prevention and treatment of skeletal-related events in patients with bone metastases from breast cancer. In light of these advances, the American Society of Clinical Oncology has published a guideline update.

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  • 14 July 2011

    In the online and print versions of this article initially published, the name and email address of the corresponding author (L. J. Suva; suvalarryj@uams.edu) were missing. The error has been corrected for the HTML and PDF versions of the article.

References

  1. Suva, L. J., Washam, C., Nicholas, R. W. & Griffin, R. J. Bone metastasis: mechanisms and therapeutic opportunities. Nat. Rev. Endocrinol. 7, 208–218 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Hortobagyi, G. N. et al. Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. Protocol 19 Aredia Breast Cancer Study Group. N. Engl. J. Med. 335, 1785–1791 (1996).

    Article  CAS  PubMed  Google Scholar 

  3. Lipton, A., Cook, R. J., Major, P., Smith, M. R. & Coleman, R. E. Zoledronic acid and survival in breast cancer patients with bone metastases and elevated markers of osteoclast activity. Oncologist 12, 1035–1043 (2007).

    Article  CAS  PubMed  Google Scholar 

  4. Hillner, B. E. et al. American Society of Clinical Oncology guideline on the role of bisphosphonates in breast cancer. American Society of Clinical Oncology Bisphosphonates Expert Panel. J. Clin. Oncol. 18, 1378–1391 (2000).

    Article  CAS  PubMed  Google Scholar 

  5. Hillner, B. E. et al. American Society of Clinical Oncology 2003 update on the role of bisphosphonates and bone health issues in women with breast cancer. J. Clin. Oncol. 21, 4042–4057 (2003).

    Article  CAS  PubMed  Google Scholar 

  6. Van Poznak, C. H. et al. American society of clinical oncology executive summary of the clinical practice guideline update on the role of bone-modifying agents in metastatic breast cancer. J. Clin. Oncol. 29, 1221–1227 (2011).

    Article  CAS  PubMed  Google Scholar 

  7. Stopeck, A. T. et al. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. J. Clin. Oncol. 28, 5132–5139 (2010).

    Article  CAS  PubMed  Google Scholar 

  8. Cummings, S. R. et al. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N. Engl. J. Med. 361, 756–765 (2009).

    Article  CAS  PubMed  Google Scholar 

  9. Shane, E. et al. Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J. Bone Miner. Res. 25, 2267–2294 (2010).

    Article  PubMed  Google Scholar 

  10. Body, J. J. et al. Effects of denosumab in patients with bone metastases with and without previous bisphosphonate exposure. J. Bone Miner. Res. 25, 440–446 (2010).

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Larry J. Suva.

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Suva, L., Brander, B. & Makhoul, I. Update on bone-modifying agents in metastatic breast cancer. Nat Rev Endocrinol 7, 380–381 (2011). https://doi.org/10.1038/nrendo.2011.80

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