Advances in the development of bone-modifying agents have led to the approval of new drugs for the prevention and treatment of skeletal-related events in patients with bone metastases from breast cancer. In light of these advances, the American Society of Clinical Oncology has published a guideline update.
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14 July 2011
In the online and print versions of this article initially published, the name and email address of the corresponding author (L. J. Suva; suvalarryj@uams.edu) were missing. The error has been corrected for the HTML and PDF versions of the article.
References
Suva, L. J., Washam, C., Nicholas, R. W. & Griffin, R. J. Bone metastasis: mechanisms and therapeutic opportunities. Nat. Rev. Endocrinol. 7, 208–218 (2011).
Hortobagyi, G. N. et al. Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. Protocol 19 Aredia Breast Cancer Study Group. N. Engl. J. Med. 335, 1785–1791 (1996).
Lipton, A., Cook, R. J., Major, P., Smith, M. R. & Coleman, R. E. Zoledronic acid and survival in breast cancer patients with bone metastases and elevated markers of osteoclast activity. Oncologist 12, 1035–1043 (2007).
Hillner, B. E. et al. American Society of Clinical Oncology guideline on the role of bisphosphonates in breast cancer. American Society of Clinical Oncology Bisphosphonates Expert Panel. J. Clin. Oncol. 18, 1378–1391 (2000).
Hillner, B. E. et al. American Society of Clinical Oncology 2003 update on the role of bisphosphonates and bone health issues in women with breast cancer. J. Clin. Oncol. 21, 4042–4057 (2003).
Van Poznak, C. H. et al. American society of clinical oncology executive summary of the clinical practice guideline update on the role of bone-modifying agents in metastatic breast cancer. J. Clin. Oncol. 29, 1221–1227 (2011).
Stopeck, A. T. et al. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. J. Clin. Oncol. 28, 5132–5139 (2010).
Cummings, S. R. et al. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N. Engl. J. Med. 361, 756–765 (2009).
Shane, E. et al. Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J. Bone Miner. Res. 25, 2267–2294 (2010).
Body, J. J. et al. Effects of denosumab in patients with bone metastases with and without previous bisphosphonate exposure. J. Bone Miner. Res. 25, 440–446 (2010).
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Suva, L., Brander, B. & Makhoul, I. Update on bone-modifying agents in metastatic breast cancer. Nat Rev Endocrinol 7, 380–381 (2011). https://doi.org/10.1038/nrendo.2011.80
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DOI: https://doi.org/10.1038/nrendo.2011.80
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