Bisphosphonates

Definition

Bisphosphonates are a class of drugs, structurally similar to pyrophosphate, that inhibit osteoclast-mediated bone resorption by binding with high affinity to the hydroxyapatite crystals of bone mineral. Bisphosphonates are used in the therapy of a range of metabolic bone diseases, notably osteoporosis, and as bone-imaging agents.

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