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Diabetes

Insulin pump therapy for type 2 diabetes mellitus

Nature Reviews Endocrinology volume 10, pages 647–649 (2014)Cite this article

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The evidence base for the efficacy of insulin pump therapy in type 2 diabetes mellitus (T2DM) has been inconsistent to date. However, a recent large-scale randomized controlled trial comparing pump treatment with multiple daily insulin injections in patients with poorly controlled T2DM has shown substantial improvement in glycaemic control with pump therapy.

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References

  1. Pickup, J. C. Insulin-pump therapy for type 1 diabetes mellitus. N. Engl. J. Med. 366, 1616–1624 (2012).

    Article  CAS  Google Scholar 

  2. National Institute for Health and Care Excellence. Continuous subcutaneous insulin infusion for the treatment of diabetes mellitus. NICE Technology Appraisals [TA151] [online], (2008).

  3. Raskin, P. et al. Continuous subcutaneous insulin infusion and multiple daily injection therapy are equally effective in type 2 diabetes: a randomized, parallel-group, 24-week study. Diabetes Care 26, 2598–2603 (2003).

    Article  CAS  Google Scholar 

  4. Berthe, E. et al. Effectiveness of intensive insulin therapy by multiple daily injections and continuous subcutaneous insulin infusion: a comparison study in type 2 diabetes with conventional insulin regimen failure. Horm. Metab. Res. 39, 224–229 (2007).

    Article  CAS  Google Scholar 

  5. Reznik, Y. et al. Insulin pump treatment compared with multiple daily insulin injections for the treatment of type 2 diabetes (OpT2mise): a randomised open-label controlled trial. Lancet http://dx.doi.org/10.1016/S0140–6736(14)61037–0.

  6. Dodd, A. H. et al. Treatment approach and HbA1c control among US adults with type 2 diabetes: NHANES 1999–2004. Curr. Med. Res. Opin. 25, 1605–1613 (2009).

    Article  CAS  Google Scholar 

  7. Edelman, S. et al. Insulin pump therapy in patients with type 2 diabetes. Safely improved glycemic control using a simple insulin dosing regimen. Diabet. Technol. Therapeut. 12, 627–633 (2010).

    Article  CAS  Google Scholar 

  8. Leinung, M. et al. Use of insulin pump therapy in patients with type 2 diabetes after failure of multiple daily injections. Endocr. Pract. 19, 9–13 (2013).

    Article  Google Scholar 

  9. Parkner, T. et al. Insulin and glucose profiles during continuous subcutaneous insulin infusion compared with injection of a long-acting insulin in type 2 diabetes. Diabet. Med. 25, 585–591 (2008).

    Article  CAS  Google Scholar 

  10. King, A. B., Clark, D. & Wolfe, G. S. The number of basal rates required to achieve near-normal basal glucose control in pump-treated type 2 diabetes. Diabet. Technol. Therapeut. 14, 900–903 (2012).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Diabetes Research Group, King's College London School of Medicine, Hodgkin Building, Guy's Hospital, SE1 1UL, London, UK

    John C. Pickup

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  1. John C. Pickup
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Correspondence to John C. Pickup.

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Competing interests

J.C.P. has received speaker and/or consultancy fees from manufacturers of insulin pumps, including Cellnovo, Cequr, Medtronic and Roche.

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Pickup, J. Insulin pump therapy for type 2 diabetes mellitus. Nat Rev Endocrinol 10, 647–649 (2014). https://doi.org/10.1038/nrendo.2014.142

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