Reviews & Analysis

This PrimeView highlights the epidemiology of Creutzfeldt-Jakob disease and other prion diseases, a group of rare neurological disorders.

This Primer by Zerr et al. discusses the epidemiology, pathophysiology, diagnosis and potential future treatments for Creutzfeldt–Jakob disease and other human prion diseases.

This PrimeView highlights the epidemiology of Attention-deficit/hyperactivity disorder.

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that typically starts in childhood. This Primer summarizes the epidemiology, mechanisms, diagnosis and treatment of ADHD.

This PrimeView highlights the pathophysiology of rotator cuff tears and accompanies the Primer article on this topic by Feeley and colleagues.

Rotator cuff tears occur due to trauma or, most commonly, due to degenerative changes to tendon structure. This Primer summarizes the epidemiology and pathophysiology of this condition, discusses its diagnosis and management, and highlights patients’ quality of life and future research questions.

This PrimeView highlights the epidemiology of strongyloidiasis, as well as discussing mechanisms, diagnosis, management and outlook.

Strongyloidiasis is a helminth infection that is most common in tropical and subtropical regions. In this Primer, Gordon et al. review the global disease burden and risk factors, summarize the pathophysiology, diagnosis and prevention of this parasite infection, and provide an overview of its treatment and areas for future work.

This PrimeView highlights the mechanisms of perioperative stroke, and accompanies the Primer on this topic by Fanning et al.

Perioperative stroke — that is stroke occurring during or within 30 days of surgery — is associated with poor outcomes. This Primer summarizes the epidemiology, mechanisms, diagnosis and treatment of perioperative stroke.

This PrimeView highlights the pathophysiology of pulmonary hypertension, as well as discussing epidemiology, diagnosis, management and quality of life.

Pulmonary hypertension describes a group of disorders characterized by elevated mean pulmonary artery pressure. This Primer reviews the epidemiology and pathophysiology of pulmonary hypertension, discusses diagnosis and management, and provides an overview of current open research questions.