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The HIV pipeline

Nature Reviews Drug Discovery volume 13, pages 649–650 (2014)Cite this article

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About 34 million people worldwide are infected with HIV. The hallmark of HIV infection is a progressive decline in CD4+ T cells and, to a lesser extent, CD8+ T cells and peripheral blood mononuclear cells. The deterioration of the immune system leads to life-threatening opportunistic infections and AIDS.

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Figure 1: Mechanisms of action in the pipeline.

References

  1. World Health Organization. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. WHO [online], (2013).

  2. Araújo, L. A. L. & Almeida, S. E. M. HIV-1 diversity in the envelope glycoproteins: implications for viral entry inhibition. Viruses 5, 595–604 (2013).

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  3. GBI research. HIV therapeutics in major developed market to 2019. GBIHC328MR (2014).

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Authors and Affiliations

  1. Angel Wong is an analyst at GBI Research, Bolton, BL1 2AH, UK.,

    Angel Wong

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  1. Angel Wong
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Correspondence to Angel Wong.

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The author declares no competing financial interests.

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Wong, A. The HIV pipeline. Nat Rev Drug Discov 13, 649–650 (2014). https://doi.org/10.1038/nrd4364

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