Abstract
In November 2011, ruxolitinib (Jakafi; Incyte/Novartis), a small-molecule inhibitor of Janus kinases, was approved by the US Food and Drug Administration for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythaemia vera myelofibrosis and post-essential thrombocythaemia myelofibrosis.
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References
Vannucchi, A. M. et al. Advances in understanding and management of myeloproliferative neoplasms. CA Cancer J. Clin. 59, 171–191 (2009).
Quintás-Cardama, A. et al. Janus kinase inhibitors for the treatment of myeloproliferative neoplasias and beyond. Nature Rev. Drug Discov. 10, 127–140 (2011).
Quintás-Cardama, A. et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood 115, 3109–3117 (2010).
US Food and Drug Administration. FDA labeling information — Jakafi. FDA website [online], (2011).
Verstovsek, S. et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N. Engl. J. Med. 363, 1117–1127 (2010).
Silver, R. T. et al. Recombinant interferon-alpha may retard progression of early primary myelofibrosis: a preliminary report. Blood 117, 6669–6672 (2011).
Mesa, R. A. et al. Lenalidomide and prednisone for myelofibrosis: Eastern Cooperative Oncology Group (ECOG) Phase 2 trial E4903. Blood 116, 4436–4438 (2010).
Cervantes, F. et al. Efficacy and tolerability of danazol as a treatment for the anaemia of myelofibrosis with myeloid metaplasia: long-term results in 30 patients. Br. J. Haematol. 129, 771–775 (2005).
Thepot, S. et al. Treatment of progression of Philadelphia-negative myeloproliferative neoplasms to myelodysplastic syndrome or acute myeloid leukemia by azacitidine: a report on 54 cases on the behalf of the Groupe Francophone des Myelodysplasies (GFM). Blood 116, 3735–3742 (2010).
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Supplementary information Figure S1
First-line therapy of myelofibrosis in 2012. (PDF 702 kb)
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Mesa, R., Yasothan, U. & Kirkpatrick, P. Ruxolitinib. Nat Rev Drug Discov 11, 103–104 (2012). https://doi.org/10.1038/nrd3652
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DOI: https://doi.org/10.1038/nrd3652
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