Microscopic deposits of tumor cells in regional lymph nodes can be detected using immunohistochemical techniques in patients without conventional histopathological evidence of lymph-node involvement. In the case of bile duct cancer, these micrometastases have an intermediate prognostic significance between that of positive and negative conventional pathology.
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Silva, M., Friend, P. Does nodal micrometastasis impact outcome in biliary cancer?. Nat Rev Clin Oncol 7, 680–681 (2010). https://doi.org/10.1038/nrclinonc.2010.184
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DOI: https://doi.org/10.1038/nrclinonc.2010.184