The marriage of medicinal chemistry, molecular biology and medicine is perhaps best exemplified by the evolution of selective oestrogen-receptor modulators (SERMs). Translational studies might be useful for predicting the myriad clinical responses to SERMs, contributing to improvements in women's health.
Key Points
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Raloxifene must not be used to prevent breast cancer in high-risk premenopausal women
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Tamoxifen is the only selective oestrogen-receptor modulator available to prevent breast cancer in premenopausal women
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Acknowledgements
The author is supported by the Department of Defense Breast Program (award number W81XWH-06-1-0590) Center of Excellence, the Susan G. Komen for the Cure Foundation (award number SAC100009), Georgetown–Howard Universities Center for Clinical and Translational Science Clinical and Translational Science Awards (grant UL1RR031975) and the Lombardi Comprehensive Cancer Center Support Grant (core grant NIH P30 CA051008). The views and opinions of the author do not reflect those of the US Army or the Department of Defense.
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Jordan, V. Any surprises from selective oestrogen-receptor modulators?. Nat Rev Clin Oncol 10, 432–434 (2013). https://doi.org/10.1038/nrclinonc.2013.94
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DOI: https://doi.org/10.1038/nrclinonc.2013.94