Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Decade in review—cardiomyopathies

Cardiomyopathy on the move

Nature Reviews Cardiology volume 11, pages 628–629 (2014)Cite this article

Subjects

Since Wallace Brigden first used the term 'cardiomyopathy' in 1952, this group of diseases has continued to attract the interest of clinicians, researchers, and importantly, patients. The past decade has seen a substantial accumulation of knowledge relating to various cardiomyopathies, which has partially lifted the mystery surrounding this topic.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Genetic mechanisms of cardiomyopathies.

References

  1. Cecchi, F., Tomberli, B. & Olivotto, I. Clinical and molecular classification of cardiomyopathies. Glob. Cardiol. Sci. Pract. 2012, 4 (2012).

    Article  Google Scholar 

  2. Herman, D. S. et al. Truncations of titin causing dilated cardiomyopathy. N. Engl. J. Med. 366, 619–628 (2012).

    Article  CAS  Google Scholar 

  3. Golbus, J. R. et al. Population-based variation in cardiomyopathy genes. Circ. Cardiovasc. Genet. 5, 391–399 (2012).

    Article  Google Scholar 

  4. Pan, S. et al. Cardiac structure and sarcomeric genes associated with cardiomyopathy exhibit marked intolerance of genetic variation. Circ. Cardiovasc. Genet. 5, 602–610 (2012).

    Article  Google Scholar 

  5. Kalozoumi, G., Tzimas, C. & Sanoudou, D. The expanding role of epigenetics. Glob. Cardiol. Sci. Pract. 2012, 7 (2012).

    Article  Google Scholar 

  6. Olivotto, I. et al. Developmental origins of hypertrophic cardiomyopathy phenotypes: a unifying hypothesis. Nat. Rev. Cardiol. 6, 317–321 (2009).

    Article  CAS  Google Scholar 

  7. Teekakirikul, P. et al. Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β. J. Clin. Invest. 120, 3520–3529 (2010).

    Article  CAS  Google Scholar 

  8. Gaendrarao, P. et al. Molecular modeling of disease causing mutations in domain C1 of cMyBP-C. PLoS ONE 8, e59206 (2013).

    Article  Google Scholar 

  9. Coppini, R. et al. Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy. Circulation 127, 575–584 (2013).

    Article  CAS  Google Scholar 

  10. Jiang, J. et al. Allele-specific silencing of mutant Myh6 transcripts in mice suppresses hypertrophic cardiomyopathy. Science 342, 111–114 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Qatar Cardiovascular Research Center, PO Box 5825, Doha, Qatar

    Magdi H. Yacoub

Authors
  1. Magdi H. Yacoub
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Magdi H. Yacoub.

Ethics declarations

Competing interests

The author declares no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yacoub, M. Cardiomyopathy on the move. Nat Rev Cardiol 11, 628–629 (2014). https://doi.org/10.1038/nrcardio.2014.157

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrcardio.2014.157

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing