Volume 16 Issue 5, May 2016

A recent publication inNature Medicine in which Seyedmehdi Shojaee, Markus Müschen and colleagues show that deletion of the tumour suppressor PTENin pre-B cell acute lymphoblastic leukaemia (pre-B ALL) cells results in cell death.

Two studies report that the nuclear envelope undergoes rupture and resealing when migrating cells pass through tight spaces.

This Review assesses the mechanism-based biomarkers in use and in development for immune checkpoint inhibition, identifying cancer types and cancer phenotypes that are most likely to respond to immune checkpoint blockade, and considerations for future biomarkers of immune checkpoint response.

This Review summarizes our current understanding of the molecular mechanisms that regulate translation in cancer cells. The authors highlight the technological advances that have fuelled progress in this field and discuss how cancer cells tailor translation to adapt to oncogenic stress.

This Review discusses our current understanding of oesophageal adenocarcinoma and intestinal-type gastric cancer, integrating advances from cell-of-origin studies and comprehensive genomic alteration analyses, with the goal of providing insight into the relationships between these two cancers.

This Opinion article discusses the challenges in determining which genomic events in tumours are actionable and thus expected to affect treatment response. The authors summarize published classification approaches and propose a new framework to classify mutation actionability in early-phase clinical trials.

The incidence of many cancer types in non-reproductive tissues is higher in males than in females. This Opinion article discusses the cellular and molecular differences between the two sexes that might contribute to this discrepancy.