Surgical androgen deprivation therapy (ADT) has activating effects on the immune system. However, whether medical ADT (with androgen receptor (AR) antagonists) has similar effects is not clear. Pu et al. report the unexpected finding that AR antagonists suppress immune responses by inhibiting T cell activation. Furthermore, surgical ADT synergized with immunotherapy in mouse models of prostate cancer, whereas medical ADT suppressed immunotherapy effects. These findings might improve prostate cancer immunotherapy.
References
Pu, Y. et al. Androgen receptor antagonists compromise T cell response against prostate cancer leading to early tumor relapse. Sci. Transl Med. 8, 333ra47 (2016)
Rights and permissions
About this article
Cite this article
Seton-Rogers, S. Connecting androgen receptor and immunity. Nat Rev Cancer 16, 273 (2016). https://doi.org/10.1038/nrc.2016.46
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrc.2016.46
